Percorrer por autor "Bártolo, Paulo"
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- Alginate/Aloe Vera Hydrogel Films for Biomedical ApplicationsPublication . Pereira, Rúben F.; Mendes, Ausenda; Bártolo, PauloThis paper describes a methodology to produce hydrogel films, composed of alginate and Aloe vera, for wound healing and drug delivery applications. The films were prepared through the solvent-casting method and subsequently submitted to an additional cross-linking step to improve their properties. Alginate films with different Aloe vera contents (5, 15 and 25%) were prepared and its properties evaluated in terms of thickness, transparency, swelling behavior and in vitro degradation. Results show a positive influence of Aloe vera on the transparency of the films, in both dry and wet state. Films were immersed in acetate buffer at pH 5.5 simulating the value of the skin, to evaluate its water absorption capacity. It was found that water absorption increases as the Aloe vera content increases, suggesting that Aloe vera enhances the hydrophilic properties of the films. The in vitro degradation tests were performed through the incubation of the films, for 10 weeks, in a simulated body fluid at 37°C. After this period, films kept its structure integrity exhibiting a weight loss in the range of 14.1-18.6%.
- BiomanufacturingPublication . Mitsuishi, Mamoru; Cao, Jian; Bártolo, Paulo; Friedrich, Dirk; Shih, Albert J.; Rajurkar, Kamlakar; Sugita, Naohiko; Harada, KanakoBiomedical markets are large and rapidly growing owing to increasing demand for better healthcare services. The development of innovative biomedical systems can produce major breakthroughs in the healthcare industry, and advanced manufacturing technologies can propel such innovations. This paper summarises the field of biomanufacturing: namely, biospecific design constraints, biomechatronics, biofabrication, biodesign, and assembly. This paper presents state-of-the-art research, current problems, and future goals while providing fundamental knowledge required for entry into the biomedical industry. Biomanufacturing provides excellent opportunities for multi-disciplinary collaborations, both in academia and industry, and can lead to further advances in many engineering fields.
- Biopolymer-based manufacturing system for medical applicationsPublication . Lagoa, Ricardo; Bártolo, Paulo; Mendes, Ausenda
- Cranial Biomechanical SimulationPublication . Perestrelo, Pedro; Bártolo, Paulo; Paranhos, Maurício; Noritomi, Pedro; Silva, JorgeIn order to improve the understanding, detection and prevention of traumatic brain injury (TBI), a step forward must be taken in the research. A pursue of biomechanical and clinical theories in separate, must give place to a joined effort. Therefore, it is proposed the development of a virtual platform using BioCAD protocol, surface modeling software and finite element method (FEM) analysis software, in order to achieve a model that can be adapted to the needs of the user or patient. This will result in an innovative and most needed tool, so that research and prevention of TBI enter a new level.
- Development of novel alginate based hydrogel films for wound healing applicationsPublication . Pereira, Rúben; Carvalho, Anabela; Vaz, Daniela C.; Gil, M. H.; Mendes, Ausenda; Bártolo, PauloAlginate and Aloe vera are natural materials widely investigated and used in the biomedical field. In this research work, thin hydrogel films composed by alginate and Aloe vera gel in different proportions (95:5, 85:15 and 75:25, v/v) were prepared and characterized. The films were evaluated regarding the light transmission behavior, contact angle measurements, and chemical, thermal and mechanical properties. These thin hydrogel films, prepared by crosslinking reaction using 5% calcium chloride solution, were also investigated relatively to their water solubility and swelling behavior. Results showed that Aloe vera improved the transparency of the films, as well their thermal stability. The developed films present adequate mechanical properties for skin applications, while the solubility studies demonstrated the insolubility of the films after 24 h of immersion in distilled water. The water absorption and swelling behavior of these films were greatly improved by the increase in Aloe vera proportion.
- EditorialPublication . Bártolo, Paulo; Chua, C. K.In this issue, we invited five winners of the ‘Best Paper Awards’ at the 4th International Conference on Advanced Research in Virtual and Rapid Prototyping, Leiria, Portugal, 6-10 October 2009, to enhance their conference papers to the standard of an international journal. One paper each from ‘Materials’ track, ‘Biomanufacturing’ track and ‘Virtual Environment & Simulation’ track and two papers from ‘Advanced Rapid Prototyping Technologies and Nanofabrication’ track.
- EditorialPublication . Bártolo, Paulo; Chua, C. K.As time goes on, the relevance of the Virtual and Physical Prototyping journal increases. This Journal was submitted to Thomson Scientific to be accepted as an ISI Journal and the number of conferences asking for our endorsement is growing fast, such as the following: . International Conference on Additive Technologies, IC AT2010, 22 24 September 2010, Nova Gorica, Slovenia . Virtual Concept 2010, 20-22 October 2010, Bordeaux, France Both conferences will be endorsed by Virtual and Physical Prototyping, as will the 5th International Conference on Advanced Research in Virtual and Rapid Prototyping (VRAP Conference), which will be held at Leiria by the Centre for Rapid and Sustainable Product Development of the Polytechnic Institute of Leiria, from 28 September to 1 October 2011.
- EditorialPublication . Bártolo, Paulo; Chua, C.K.The year of 2012 is a fruitful year for Virtual & Physical Prototyping. The journal has maintained its usual publication record and published a total of twenty-three original research articles (including this issue). Similarly, total citations to this journal in Year 2012 have also maintained at a near-hundred level by the mid-October (Scopus). The stabilized publication record and total citations demonstrate a mature and healthy status of the journal. In this regard, we thank all authors who have made contributions to this journal.
- EditorialPublication . Bártolo, Paulo; C. K. Chua
- EditorialPublication . Bártolo, Paulo; Chua, C.K.Additive manufacturing (AM) technologies play a key role in the advancement of biomedical applications. In this issue, we share with the readers the roles of AM technologies in two applications for biomedical engineering, namely scaffolds for tissue engineering and a composite model for club foot.
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