Red seaweed-derived compounds as a potential new approach for acne vulgaris care

Januário, Adriana P.; Félix, Rafael; Félix, Carina; Reboleira, João; Valentão, Patrícia; Lemos, Marco F.L.

http://hdl.handle.net/10400.8/7542

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Abstract(s)

Acne vulgaris (AV) is a chronic skin disease of the pilosebaceous unit affecting both adolescents and adults. Its pathophysiology includes processes of inflammation, increased keratinization, sebum production, hormonal dysregulation, and bacterial Cutibacterium acnes proliferation. Common AV has been treated with antibiotics since the 1960s, but strain resistance has emerged and is of paramount concern. Macroalgae are known producers of substances with bioactive properties, including anti-viral, antibacterial, antioxidant, and anti-inflammatory properties, among several others. In particular, red algae are rich in bioactive compounds such as polysaccharides, phenolic compounds, lipids, sterols, alkaloids, and terpenoids, conferring them antioxidant, antimicrobial, and anti-inflammatory activities, among others. Thus, the exploration of compounds from marine resources can be an appealing approach to discover new treatment options against AV. The aim of this work is to provide an overview of the current knowledge of the potentialities of red macroalgae in the treatment of AV by reviewing the main therapeutic targets of this disease, and then the existence of compounds or extracts with bioactive properties against them.

Description

Funding: This study had the support of the Fundação para a Ciência e a Tecnologia (FCT) Strategic Projects UID/MAR/04292/2020 and UIDB/50006/2020 granted to MARE and REQUIMTE, respectively; the grant awarded to A.P.J. (2020.08202.BD); and project MARINE INVADERS (POCI-01-0145-FEDER-031144). The authors also wish to acknowledge the support of the European Union through EASME Blue Labs project AMALIA, Algae-to-MArket Lab IdeAs (EASME/EMFF/2016/1.2.1.4/03/SI2.750419). The project was also partially funded by RDandT co-promotion project ORCHESTRA (POCI-01-0247-FEDER-070155) through COMPETE, Portugal 2020 and FCT, and COSMOS (MAR-04.03.01-FEAMP-0370) through GAL PESCA OESTE and MAR2020 in the framework of PORTUGAL2020 and the European Maritime and Fisheries Fund.

Keywords

Acne pathophysiology Antibacterial Bioactive compounds Cutibacterium acnes Inflammation Rhodophyta Seaweed extracts

URI

http://hdl.handle.net/10400.8/7542

Citation

Januário, A.P.; Félix, R.; Félix, C.; Reboleira, J.; Valentão, P.; Lemos, M.F.L. Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care. Pharmaceutics 2021, 13, 1930. https://doi.org/10.3390/pharmaceutics13111930