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Effect of home-based exercise prehabilitation on postoperative outcomes in colorectal cancer surgery: a systematic review and meta-analysis

2024-12-12Journal article Open access
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dc.contributor.authorMachado, Pedro
dc.contributor.authorPaixão, André
dc.contributor.authorOliveiros, Bárbara
dc.contributor.authorMartins, Raul A.
dc.contributor.authorCruz, Joana
dc.date.accessioned2025-01-29T16:34:12Z
dc.date.available2025-01-29T16:34:12Z
dc.date.issued2024-12-12
dc.descriptionP.M. and J.C. acknowledge the support of the Centre for Innovative Care and Health Technology (ciTechCare) of the Polytechnic University of Leiria, funded by the Portuguese Foundation for Science and Technology (UIDB/05704/2020).pt_PT
dc.descriptionOpen access funding provided by FCT|FCCN (b-on). P.M. holds a PhD fellowship supported by the Portuguese Foundation for Science and Technology (REF UIDB/05704/2020). The authors have no other relevant financial or non-financial interests to disclose.pt_PT
dc.description.abstractPurpose Home-based exercise training may improve access to surgical prehabilitation in colorectal cancer (CRC) patients, but its efficacy remains unclear. This study systematically investigated the effects of home-based exercise prehabilitation on postoperative exercise capacity, complications, length of hospital stay, and health-related quality of life (HRQoL) in CRC patients. Methods Randomized controlled trials (RCTs) comparing home-based exercise prehabilitation with control in CRC patients were eligible. We searched MEDLINE, Scopus, Web of Science, PEDro, and SPORTDiscus from their inception to June 3, 2024. Methodological quality was assessed using the PEDro scale, and certainty of evidence was assessed using GRADE. Data were synthesized using random-effects meta-analyses, with sensitivity analysis on studies with good methodological quality (PEDro score ≥ 6). Results Eight RCTs involving 1092 participants were included. The primary analysis showed a significant improvement in postoperative 6-min walk distance following home-based exercise prehabilitation compared to control (mean difference (MD) = 30.62: 95% CI: [2.94; 57.79]; low-certainty evidence). However, sensitivity analysis revealed no significant between-group differences (MD = 22.60: 95% CI: [− 6.27; 51.46]). No significant effects of home-based exercise prehabilitation were found on postoperative complications (risk ratio = 1.00: 95% CI: [− 0.78; 1.29]; moderate‐certainty evidence), length of hospital stay (MD = − 0.20: 95% CI: [− 0.65; 0.23]; moderate‐certainty evidence), and HRQoL (physical functioning: MD = 2.62: 95% CI: [− 6.16; 11.39]; mental functioning: MD = 1.35: 95% CI: [− 6.95; 9.65]; low and very-low certainty evidence). Conclusion Home-based exercise prehabilitation does not reduce postoperative complications and length of hospital stay after CRC surgery. Its effects on postoperative exercise capacity and HRQoL remain uncertain due to low-quality evidence.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMachado, P., Paixão, A., Oliveiros, B. et al. Effect of home-based exercise prehabilitation on postoperative outcomes in colorectal cancer surgery: a systematic review and meta-analysis. Support Care Cancer 33, 20 (2025). https://doi.org/10.1007/s00520-024-09069-ypt_PT
dc.identifier.doihttps://doi.org/10.1007/s00520-024-09069-ypt_PT
dc.identifier.eissn1433-7339
dc.identifier.issn0941-4355
dc.identifier.urihttp://hdl.handle.net/10400.8/10442
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relationCenter for Innovative Care and Health Technology
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00520-024-09069-ypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectColorectal cancerpt_PT
dc.subjectExercise trainingpt_PT
dc.subjectPerioperative medicinept_PT
dc.subjectPrehabilitationpt_PT
dc.subjectSurgical oncologypt_PT
dc.titleEffect of home-based exercise prehabilitation on postoperative outcomes in colorectal cancer surgery: a systematic review and meta-analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCenter for Innovative Care and Health Technology
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05704%2F2020/PT
oaire.citation.issue20pt_PT
oaire.citation.titleSupportive Care in Cancerpt_PT
oaire.citation.volume33pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMachado
person.familyNameReis Franco Cruz
person.givenNamePedro
person.givenNameJoana Maria
person.identifier1763199
person.identifier.ciencia-id111A-3F47-19CD
person.identifier.ciencia-idDA1E-EE64-65FA
person.identifier.orcid0000-0003-1147-2778
person.identifier.orcid0000-0002-7191-9204
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7e59cca8-9db1-42b3-baa0-aff90405d499
relation.isAuthorOfPublication101013d0-9095-46be-b751-87e725889d8a
relation.isAuthorOfPublication.latestForDiscovery7e59cca8-9db1-42b3-baa0-aff90405d499
relation.isProjectOfPublicationd421b07d-3471-4026-aa43-def80b8e142b
relation.isProjectOfPublication.latestForDiscoveryd421b07d-3471-4026-aa43-def80b8e142b

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