Mitigating the negative impacts of marine invasive species – Sargassum muticum - a key seaweed for skincare products development

Susano, Patrícia; Silva, Joana; Alves, Celso; Martins, Alice; Pinteus, Susete; Gaspar, Helena; Goettert, Márcia Inês; Pedrosa, Rui

http://hdl.handle.net/10400.8/7578

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Authors

Goettert, Márcia Inês

Pedrosa, Rui

Abstract(s)

Sargassum muticum is a highly invasive species, threatening marine biodiversity worldwide. One strategy to reduce marine invaders’ impacts is to promote their use as valuable biomass for new products development. On the other hand, there is a rising conscience of natural compounds importance as health promoters. The present work was designed to sustainably use the marine invasive seaweed S. muticum collected off the Portuguese shore for novel skincare products. The antioxidant, anti-enzymatic (collagenase, elastase, hyaluronidase, tyrosinase), antimicrobial (Staphylococcus epidermidis, Cutibacterium acnes, Malassezia furfur), photoprotective, and antiinflammatory properties of five fractions (F1–F5) obtained by a sequential extraction of S. muticum were evaluated. The diethyl ether fraction (F2) demonstrated the most promising results, with the highest antioxidant and photoprotective capacity, reducing reactive oxygen species (ROS) production promoted by UVA and UVB radiation in 3T3 cells. On the other hand, the ethyl acetate fraction (F3) exhibited the highest anti-enzymatic capacity, inhibiting the activities of collagenase, hyaluronidase and tyrosinase (IC50 of 97.5, 23.7 and 72.3 μg/mL, respectively). Moreover, fractions from S. muticum showed anti-inflammatory potential by reducing tumor necrosis factor – α and interleukin-6 release. A chemical screening by 1H NMR of S. muticum fractions evidenced signals that can be attributed to the presence of different chemical classes, including lipids, pigments, amino acids, polyphenols, and sugars, being related to the observed multitarget properties. This work highlights a strategic valorisation of S. muticum as a source of treasured ingredients for skincare applications.

Description

Acknowledgments : This work was supported by the Portuguese Foundation for Science and Technology (FCT) through the POCI project -01-0247-FEDER070155 - ORCHESTRA - add-value to ORChards through thE full valoriSaTion of macroalgae and by FEDER – European Regional Development Fund of the European Union, under the Portugal 2020 Programme, through COMPETE 2020 – Competitiveness and Internationalization Operational Program. Also, through the FCT projects: UIDP/04292/2020 and UIDB/04292/2020 granted to MARE—Marine and Environmental Sciences Centre; UIDP/Multi/04046/2020 and UIDB/04046/2020 granted to BioISI—BioSystems and Integrative Sciences Institute; CROSS-ATLANTIC (PTDC/BIA-OUT/29250/2017), co-financed by COMPETE (POCI-01-0145-FEDER-029250); and Molecules for Health (PTDC/BIA-BQM/28355/2017). This work was also supported by FCT and CAPES cooperation agreement through project MArTics - Marine bioactive compounds for neurological disorders therapeutics FCT/DRI/CAPES 2019.00277.CBM.

Keywords

Anti-enzymatic activity Anti-inflammatory activity Dermatological bioactive natural products Marine invaders Photoprotection Oxidative stress

URI

http://hdl.handle.net/10400.8/7578

Citation

Patrícia Susano, Joana Silva, Celso Alves, Alice Martins, Susete Pinteus, Helena Gaspar, Márcia Ines Goettert, Rui Pedrosa, Mitigating the negative impacts of marine invasive species – Sargassum muticum - a key seaweed for skincare products development, Algal Research, Volume 62, 2022, 102634, ISSN 2211-9264, https://doi.org/10.1016/j.algal.2022.102634.