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Mitigating the negative impacts of marine invasive species – Sargassum muticum - a key seaweed for skincare products development

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dc.contributor.authorSusano, Patrícia
dc.contributor.authorSilva, Joana
dc.contributor.authorAlves, Celso
dc.contributor.authorMartins, Alice
dc.contributor.authorPinteus, Susete
dc.contributor.authorGaspar, Helena
dc.contributor.authorGoettert, Márcia Inês
dc.contributor.authorPedrosa, Rui
dc.date.accessioned2022-08-22T12:56:22Z
dc.date.available2022-08-22T12:56:22Z
dc.date.issued2022
dc.descriptionAcknowledgments : This work was supported by the Portuguese Foundation for Science and Technology (FCT) through the POCI project -01-0247-FEDER070155 - ORCHESTRA - add-value to ORChards through thE full valoriSaTion of macroalgae and by FEDER – European Regional Development Fund of the European Union, under the Portugal 2020 Programme, through COMPETE 2020 – Competitiveness and Internationalization Operational Program. Also, through the FCT projects: UIDP/04292/2020 and UIDB/04292/2020 granted to MARE—Marine and Environmental Sciences Centre; UIDP/Multi/04046/2020 and UIDB/04046/2020 granted to BioISI—BioSystems and Integrative Sciences Institute; CROSS-ATLANTIC (PTDC/BIA-OUT/29250/2017), co-financed by COMPETE (POCI-01-0145-FEDER-029250); and Molecules for Health (PTDC/BIA-BQM/28355/2017). This work was also supported by FCT and CAPES cooperation agreement through project MArTics - Marine bioactive compounds for neurological disorders therapeutics FCT/DRI/CAPES 2019.00277.CBM.pt_PT
dc.description.abstractSargassum muticum is a highly invasive species, threatening marine biodiversity worldwide. One strategy to reduce marine invaders’ impacts is to promote their use as valuable biomass for new products development. On the other hand, there is a rising conscience of natural compounds importance as health promoters. The present work was designed to sustainably use the marine invasive seaweed S. muticum collected off the Portuguese shore for novel skincare products. The antioxidant, anti-enzymatic (collagenase, elastase, hyaluronidase, tyrosinase), antimicrobial (Staphylococcus epidermidis, Cutibacterium acnes, Malassezia furfur), photoprotective, and antiinflammatory properties of five fractions (F1–F5) obtained by a sequential extraction of S. muticum were evaluated. The diethyl ether fraction (F2) demonstrated the most promising results, with the highest antioxidant and photoprotective capacity, reducing reactive oxygen species (ROS) production promoted by UVA and UVB radiation in 3T3 cells. On the other hand, the ethyl acetate fraction (F3) exhibited the highest anti-enzymatic capacity, inhibiting the activities of collagenase, hyaluronidase and tyrosinase (IC50 of 97.5, 23.7 and 72.3 μg/mL, respectively). Moreover, fractions from S. muticum showed anti-inflammatory potential by reducing tumor necrosis factor – α and interleukin-6 release. A chemical screening by 1H NMR of S. muticum fractions evidenced signals that can be attributed to the presence of different chemical classes, including lipids, pigments, amino acids, polyphenols, and sugars, being related to the observed multitarget properties. This work highlights a strategic valorisation of S. muticum as a source of treasured ingredients for skincare applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPatrícia Susano, Joana Silva, Celso Alves, Alice Martins, Susete Pinteus, Helena Gaspar, Márcia Ines Goettert, Rui Pedrosa, Mitigating the negative impacts of marine invasive species – Sargassum muticum - a key seaweed for skincare products development, Algal Research, Volume 62, 2022, 102634, ISSN 2211-9264, https://doi.org/10.1016/j.algal.2022.102634.pt_PT
dc.identifier.doi10.1016/j.algal.2022.102634pt_PT
dc.identifier.issn2211-9264
dc.identifier.urihttp://hdl.handle.net/10400.8/7578
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationUIDP/Multi/04046/2020pt_PT
dc.relationMarine and Environmental Sciences Centre
dc.relationMarine and Environmental Sciences Centre
dc.relationBiosystems and Integrative Sciences Institute
dc.relationPOCI-01-0145-FEDER-029250pt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2211926422000054pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAnti-enzymatic activitypt_PT
dc.subjectAnti-inflammatory activitypt_PT
dc.subjectDermatological bioactive natural productspt_PT
dc.subjectMarine invaderspt_PT
dc.subjectPhotoprotectionpt_PT
dc.subjectOxidative stresspt_PT
dc.titleMitigating the negative impacts of marine invasive species – Sargassum muticum - a key seaweed for skincare products developmentpt_PT
dc.typejournal article
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oaire.citation.titleAlgal Researchpt_PT
oaire.citation.volume62pt_PT
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