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Advisor(s)
Abstract(s)
The hypothalamus has been recognized as a regulator of whole-body aging. Neuropeptide Y (NPY), highly abundant in the central nervous system and produced by the hypothalamus, enhances autophagy in this brain region and mediates autophagy triggered by caloric restriction, suggesting a potential role as a caloric restriction mimetic and an aging regulator. Considering that hypothalamic NPY levels decline during aging, we investigated if reestablishment of NPY levels mitigate aging phenotype, using a mouse model of premature aging – Zmpste24−/− mouse. The results show that reestablishing hypothalamic NPY levels delayed aging-associated features, including lipodystrophy, alopecia, and memory. Moreover, these results suggest that strategies that promote maintenance of hypothalamic NPY levels might be relevant to counteract aging progression and age-related deteriorations.
Description
Keywords
Biology of aging Brain aging Hypothalamus Neuropeptide Y
Pedagogical Context
Citation
Ferreira-Marques, M., Carmo-Silva, S., Pereira, J. et al. Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice. GeroScience (2025). https://doi.org/10.1007/s11357-025-01574-0
Publisher
Springer Nature