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Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice

2025-02-27Journal article Open access
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg17:Parcerias para a Implementação dos Objetivos
dc.contributor.authorFerreira-Marques, Marisa
dc.contributor.authorCarmo Silva, Sara
dc.contributor.authorPereira, Joana
dc.contributor.authorBotelho, Mariana
dc.contributor.authorNóbrega, Clévio
dc.contributor.authorLópez‐Otín, Carlos
dc.contributor.authorAlmeida, Luís Pereira de
dc.contributor.authorAveleira, Célia A.
dc.contributor.authorCavadas, Cláudia
dc.date.accessioned2025-09-30T11:05:02Z
dc.date.available2025-09-30T11:05:02Z
dc.date.issued2025-02-27
dc.description.abstractThe hypothalamus has been recognized as a regulator of whole-body aging. Neuropeptide Y (NPY), highly abundant in the central nervous system and produced by the hypothalamus, enhances autophagy in this brain region and mediates autophagy triggered by caloric restriction, suggesting a potential role as a caloric restriction mimetic and an aging regulator. Considering that hypothalamic NPY levels decline during aging, we investigated if reestablishment of NPY levels mitigate aging phenotype, using a mouse model of premature aging – Zmpste24−/− mouse. The results show that reestablishing hypothalamic NPY levels delayed aging-associated features, including lipodystrophy, alopecia, and memory. Moreover, these results suggest that strategies that promote maintenance of hypothalamic NPY levels might be relevant to counteract aging progression and age-related deteriorations.eng
dc.description.sponsorshipOpen access funding provided by FCT|FCCN (b-on). This work was financed by: Progeria Research Foundation (PRF2014-53 and PRF2015-60), the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme projects CENTRO-01–0145-FEDER-000012 (HealthyAging 2020), CENTRO-01–0246-FEDER-000010 (MIA-Portugal), and COMPETE 2020 – Operational Programme for Competitiveness and Internationalisation; European Union’s Horizon 2020 research and innovation programme (grant agreement N.º 857524); FCT – Fundação para a Ciência e a Tecnologia, under project[s] POCI-01–0145-FEDER-030167 (NiNjA), UIDB/04539/2020, LA/P/0058/2020, FCT Investigator Programme (IF/00825/2015), SFRH/BD/120023/2016, COVID/BD/152130/2021. C.L-O. is supported by grants from the European Research Council (ERC Advanced Grant, DeAge), and Ministerio de Ciencia e Innovación, Spain.
dc.identifier.citationFerreira-Marques, M., Carmo-Silva, S., Pereira, J. et al. Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice. GeroScience (2025). https://doi.org/10.1007/s11357-025-01574-0
dc.identifier.doi10.1007/s11357-025-01574-0
dc.identifier.eissn2509-2723
dc.identifier.urihttp://hdl.handle.net/10400.8/14161
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Nature
dc.relationCenter for Innovative Biomedicine and Biotechnology
dc.relationCenter for Innovative Biomedicine and Biotechnology - Associate Laboratory
dc.relationNeuropeptide Y NPY system as a new target to delay aging
dc.relation.hasversionhttps://link.springer.com/article/10.1007/s11357-025-01574-0
dc.relation.ispartofGeroScience
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBiology of aging
dc.subjectBrain aging
dc.subjectHypothalamus
dc.subjectNeuropeptide Y
dc.titleRestoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in miceeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCenter for Innovative Biomedicine and Biotechnology
oaire.awardTitleCenter for Innovative Biomedicine and Biotechnology - Associate Laboratory
oaire.awardTitleNeuropeptide Y NPY system as a new target to delay aging
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04539%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0058%2F2020/PT
oaire.awardURIhttp://hdl.handle.net/10400.8/14159
oaire.citation.endPage5801
oaire.citation.issue4
oaire.citation.startPage5785
oaire.citation.titleGeroScience
oaire.citation.volume47
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCarmo Silva
person.givenNameSara
person.identifier.orcid0000-0001-6124-0428
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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relation.isProjectOfPublication1590c241-d40f-46f3-991b-313c1569908b
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