Gelidiales are not just agar: Revealing the antimicrobial potential of Gelidium corneum for skin disorders

Matias, Margarida; Pinteus, Susete; Martins, Alice; Silva, Joana; Alves, Celso; Mouga, Teresa; Gaspar, Helena; Pedrosa, Rui

http://hdl.handle.net/10400.8/7551

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Abstract(s)

In recent decades, seaweeds have proven to be an excellent source of bioactive molecules. Presently, the seaweed Gelidium corneum is harvested in a small area of the Portuguese coast exclusively for agar extraction. The aim of this work was to fully disclosure Gelidium corneum as a sustainable source of antimicrobial ingredients for new dermatological formulations, highlighting its potential to be explored in a circular economy context. For this purpose, after a green sequential extraction, these seaweed fractions (F1–F5) were chemically characterized (1H NMR) and evaluated for their antimicrobial potential against taphylococcus aureus, Staphylococcus epidermidis and Cutibacterium acnes. The most active fractions were also evaluated for their effects on membrane potential, membrane integrity and DNA damage. Fractions F2 and F3 displayed the best results, with IC50 values of 16.1 (7.27–23.02) g/mL and 51.04 (43.36–59.74) g/mL against C. acnes, respectively, and 53.29 (48.75–57.91) g/mL and 102.80 (87.15–122.30) g/mL against S. epidermidis, respectively. The antimicrobial effects of both fractions seem to be related to membrane hyperpolarization and DNA damage. This dual mechanism of action may provide therapeutic advantages for the treatment of skin dysbiosis-related diseases.

Description

Funding: This work was supported by the Portuguese Foundation for Science and Technology (FCT) through the POCI project—01-0247-FEDER-070155—ORCHESTRA—add value to ORChards through thE full valoriSaTion of macroalgae and by FEDER—European Regional Development Fund of the European Union, under the Portugal 2020 Programme, through COMPETE 2020—Competitiveness and Internationalization Operational Program. Additionally, we were also supported through the FCT projects: UIDP/04292/2020 and UIDB/04292/2020 granted to MARE—Marine and Environmental Sciences Centre; UIDP/Multi/04046/2020 and UIDB/04046/2020 granted to BioISI—Biosystems and Integrative Sciences Institute; CROSS-ATLANTIC (PTDC/BIA-OUT/29250/2017), co-financed by COMPETE (POCI-01-0145-FEDER-029250); and Molecules for Health (PTDC/BIA-BQM/28355/2017); National NMR Network (PTNMR), partially supported by Infrastructure Project N◦ 022161 (cofinanced by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). Additional support was provided by the Project Operational Programme MAR2020 through the project MAR04.03.01-FEAMP-0101–Limo do Cais.

Keywords

Marine natural products Seaweeds Skin microbia Dermatological applications Antimicrobial activity Rhodophyta Acne vulgaris Skincare Staphylococcus epidermidis Red algae

URI

http://hdl.handle.net/10400.8/7551

Citation

Matias, M.; Pinteus, S.; Martins, A.; Silva, J.; Alves, C.; Mouga, T.; Gaspar, H.; Pedrosa, R. Gelidiales Are Not Just Agar— Revealing the Antimicrobial Potential of Gelidium corneum for Skin Disorders. Antibiotics 2022, 11, 481. https://doi.org/10.3390/antibiotics11040481