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Gelidiales are not just agar: Revealing the antimicrobial potential of Gelidium corneum for skin disorders

2021Journal article Open access
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dc.contributor.authorMatias, Margarida
dc.contributor.authorPinteus, Susete
dc.contributor.authorMartins, Alice
dc.contributor.authorSilva, Joana
dc.contributor.authorAlves, Celso
dc.contributor.authorMouga, Teresa
dc.contributor.authorGaspar, Helena
dc.contributor.authorPedrosa, Rui
dc.date.accessioned2022-08-17T09:06:52Z
dc.date.available2022-08-17T09:06:52Z
dc.date.issued2021
dc.descriptionFunding: This work was supported by the Portuguese Foundation for Science and Technology (FCT) through the POCI project—01-0247-FEDER-070155—ORCHESTRA—add value to ORChards through thE full valoriSaTion of macroalgae and by FEDER—European Regional Development Fund of the European Union, under the Portugal 2020 Programme, through COMPETE 2020—Competitiveness and Internationalization Operational Program. Additionally, we were also supported through the FCT projects: UIDP/04292/2020 and UIDB/04292/2020 granted to MARE—Marine and Environmental Sciences Centre; UIDP/Multi/04046/2020 and UIDB/04046/2020 granted to BioISI—Biosystems and Integrative Sciences Institute; CROSS-ATLANTIC (PTDC/BIA-OUT/29250/2017), co-financed by COMPETE (POCI-01-0145-FEDER-029250); and Molecules for Health (PTDC/BIA-BQM/28355/2017); National NMR Network (PTNMR), partially supported by Infrastructure Project N◦ 022161 (cofinanced by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). Additional support was provided by the Project Operational Programme MAR2020 through the project MAR04.03.01-FEAMP-0101–Limo do Cais.pt_PT
dc.description.abstractIn recent decades, seaweeds have proven to be an excellent source of bioactive molecules. Presently, the seaweed Gelidium corneum is harvested in a small area of the Portuguese coast exclusively for agar extraction. The aim of this work was to fully disclosure Gelidium corneum as a sustainable source of antimicrobial ingredients for new dermatological formulations, highlighting its potential to be explored in a circular economy context. For this purpose, after a green sequential extraction, these seaweed fractions (F1–F5) were chemically characterized (1H NMR) and evaluated for their antimicrobial potential against taphylococcus aureus, Staphylococcus epidermidis and Cutibacterium acnes. The most active fractions were also evaluated for their effects on membrane potential, membrane integrity and DNA damage. Fractions F2 and F3 displayed the best results, with IC50 values of 16.1 (7.27–23.02) g/mL and 51.04 (43.36–59.74) g/mL against C. acnes, respectively, and 53.29 (48.75–57.91) g/mL and 102.80 (87.15–122.30) g/mL against S. epidermidis, respectively. The antimicrobial effects of both fractions seem to be related to membrane hyperpolarization and DNA damage. This dual mechanism of action may provide therapeutic advantages for the treatment of skin dysbiosis-related diseases.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMatias, M.; Pinteus, S.; Martins, A.; Silva, J.; Alves, C.; Mouga, T.; Gaspar, H.; Pedrosa, R. Gelidiales Are Not Just Agar— Revealing the Antimicrobial Potential of Gelidium corneum for Skin Disorders. Antibiotics 2022, 11, 481. https://doi.org/10.3390/antibiotics11040481pt_PT
dc.identifier.doi10.3390/antibiotics11040481pt_PT
dc.identifier.issn2079-6382
dc.identifier.urihttp://hdl.handle.net/10400.8/7551
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationUIDP/Multi/04046/2020pt_PT
dc.relationMarine and Environmental Sciences Centre
dc.relationMarine and Environmental Sciences Centre
dc.relationBiosystems and Integrative Sciences Institute
dc.relation.publisherversionhttps://www.mdpi.com/2079-6382/11/4/481pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMarine natural productspt_PT
dc.subjectSeaweedspt_PT
dc.subjectSkin microbiapt_PT
dc.subjectDermatological applicationspt_PT
dc.subjectAntimicrobial activitypt_PT
dc.subjectRhodophytapt_PT
dc.subjectAcne vulgarispt_PT
dc.subjectSkincarept_PT
dc.subjectStaphylococcus epidermidispt_PT
dc.subjectRed algaept_PT
dc.titleGelidiales are not just agar: Revealing the antimicrobial potential of Gelidium corneum for skin disorderspt_PT
dc.typejournal article
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oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardTitleBiosystems and Integrative Sciences Institute
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04292%2F2020/PT
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oaire.citation.issue4pt_PT
oaire.citation.titleAntibioticspt_PT
oaire.citation.volume11pt_PT
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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