CDRsp - Comunicações em conferências internacionais
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Percorrer CDRsp - Comunicações em conferências internacionais por assunto "Aloe vera"
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- Alginate/Aloe Vera Hydrogel Films for Biomedical ApplicationsPublication . Pereira, Rúben F.; Mendes, Ausenda; Bártolo, PauloThis paper describes a methodology to produce hydrogel films, composed of alginate and Aloe vera, for wound healing and drug delivery applications. The films were prepared through the solvent-casting method and subsequently submitted to an additional cross-linking step to improve their properties. Alginate films with different Aloe vera contents (5, 15 and 25%) were prepared and its properties evaluated in terms of thickness, transparency, swelling behavior and in vitro degradation. Results show a positive influence of Aloe vera on the transparency of the films, in both dry and wet state. Films were immersed in acetate buffer at pH 5.5 simulating the value of the skin, to evaluate its water absorption capacity. It was found that water absorption increases as the Aloe vera content increases, suggesting that Aloe vera enhances the hydrophilic properties of the films. The in vitro degradation tests were performed through the incubation of the films, for 10 weeks, in a simulated body fluid at 37°C. After this period, films kept its structure integrity exhibiting a weight loss in the range of 14.1-18.6%.
- Degradation Behavior of Biopolymer-based Membranes for Skin Tissue RegenerationPublication . Pereira, Rúben F.; Bártolo, Paulo J.This research work investigates the long term in vitro degradation behavior of alginate-aloe vera composite membranes for skin regeneration. The membranes were prepared through a two-step procedure, which involves the synthesis of thin membranes and the crosslinking reaction. Degradation tests were performed through the immersion of the membranes into simulated body fluid solution at pH 7.4 and physiological temperature, during 6 months. Alginate-aloe vera membranes are resistant to the hydrolytic degradation and exhibit weight loss values in a range of 20.37-26.32%. Results show that an increase in the aloe vera content leads to a slight increase in the weight loss during the degradation process. Preliminary drug release studies, using nitrofurazone as a model drug, suggest the ability of the developed membranes to be used as a drug delivery system.
- Evaluating the Properties of an Alginate Wound Dressing for Skin RepairPublication . Pereira, Rúben F.; Mendes, Ausenda; Bártolo, Paulo J.The treatment of skin lesions is a costly and complex process, for which different strategies are currently available. In this study, we investigated the properties of novel films composed of alginate and aloe vera gel for application as wound dressing material. The films combine the occlusive and haemostatic properties of calcium alginate gels with the therapeutic properties of aloe vera. We expect that these films may improve the healing process through the release of aloe vera compounds directly into the wound bed and could be an alternative to the administration of synthetic drugs to infected wounds. The films exhibited high transparency in both dry and wet state, as well as adequate mechanical properties for skin use. The results indicated that the films present great potential to be explored as wound dressing material.