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- Computational technologies in tissue engineeringPublication . Almeida, H. A.; Bártolo, P. J.In last decades, many advances have been made in order to aid the medical community. Numerous computational technologies have been developed and improved the efficiency in diagnostic and treatment of many diseases. Many of the technologies were developed with the main goal of aiding in the research of genetic and viral diseases. Tissue engineering is a multidisciplinary field that requires the combined effort of cell biologists, engineers, material scientists, mathematicians, geneticists, and clinicians toward the development of biological substitutes that restore, maintain, or improve tissue function. The success of this emerging medical domain relies on the current technological advances. This paper presents an overview of the existing computational technologies that have been implemented in tissue engineering and the design of scaffolds for tissue engineering applications. These computational technologies contemplate medical imaging processing, numerical calculations (structural, vascular and topological) and biofabrication techniques necessary for the scaffolds optimum design and production.
- OPTIMALMOULD | Cooling System Influence in Injection Moulding Cycle Time OptimizationPublication . Ramos, Carina; Carreira, Pedro; Bártolo, Paulo J.; Alves, NunoMost works undertaken on injection moulding cooling time optimization aimed at reducing the time required to produce plastic parts, this way minimizing industrial costs. An optimal cooling system is proposed to improve the injection moulding design. A multi-objective genetic algorithm called NSGA-II is used, to obtain the optimal parameters in the optimal-mould design. This new design method is an efficient tool to get optimal parameters for injection moulding design. A real case study was carried out to test the optimization platform.
- PCL and PCL/PLA Scaffolds for Bone Tissue RegenerationPublication . Patrício, Tatiana; Gloria, Antonio; Bártolo, Paulo J.This paper investigates the use of PCL and PCL/PLA scaffolds, produced using a novel additive biomanufacturing system called BioCell Printing, for bone tissue engineering applications. Results show that the BioCell Printing system produces scaffolds with regular and reproducible architecture, presenting no toxicity and enhancing cell attachment and proliferation. It was also possible to observe that the addition of PLA to PCL scaffolds strongly improves the biomechanical performance of the constructs.
- Evaluating the Properties of an Alginate Wound Dressing for Skin RepairPublication . Pereira, Rúben F.; Mendes, Ausenda; Bártolo, Paulo J.The treatment of skin lesions is a costly and complex process, for which different strategies are currently available. In this study, we investigated the properties of novel films composed of alginate and aloe vera gel for application as wound dressing material. The films combine the occlusive and haemostatic properties of calcium alginate gels with the therapeutic properties of aloe vera. We expect that these films may improve the healing process through the release of aloe vera compounds directly into the wound bed and could be an alternative to the administration of synthetic drugs to infected wounds. The films exhibited high transparency in both dry and wet state, as well as adequate mechanical properties for skin use. The results indicated that the films present great potential to be explored as wound dressing material.