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Orientador(es)
Resumo(s)
This paper describes a methodology to produce hydrogel films, composed of alginate and Aloe vera, for wound healing and drug delivery applications. The films were prepared through the solvent-casting method and subsequently submitted to an additional cross-linking step to improve their properties. Alginate films with different Aloe vera contents (5, 15 and 25%) were prepared and its properties evaluated in terms of thickness, transparency, swelling behavior and in vitro degradation. Results show a positive influence of Aloe vera on the transparency of the films, in both dry and wet state. Films were immersed in acetate buffer at pH 5.5 simulating the value of the skin, to evaluate its water absorption capacity. It was found that water absorption increases as the Aloe vera content increases, suggesting that Aloe vera enhances the hydrophilic properties of the films. The in vitro degradation tests were performed through the incubation of the films, for 10 weeks, in a simulated body fluid at 37°C. After this period, films kept its structure integrity exhibiting a weight loss in the range of 14.1-18.6%.
Descrição
Palavras-chave
Alginate Aloe vera Films Hydrogels Wound healing
Contexto Educativo
Citação
úben Pereira, Ausenda Mendes, Paulo Bártolo, Alginate/Aloe Vera Hydrogel Films for Biomedical Applications, Procedia CIRP, Volume 5, 2013, Pages 210-215, ISSN 2212-8271, https://doi.org/10.1016/j.procir.2013.01.042.
Editora
Elsevier