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- VRainSUD: Content validation of a Cognitive Training Program using the Delphi MethodPublication . Caetano, Tânia; Pinho, Maria Salomé; Freire, Hugo; Mota, Dany; Ramadas, Eduardo; Lopes, Jessica; Dixe, Maria dos Anjos; Ballin, Daniel; Macredie, Robert D.Substance abuse has undeniable effects on several cognitive domains, with these associated deficits contributing to poorer treatment outcomes in substance use disorders (SUD). Cognitive training programs (CTPs) address these cognitive deficits, contributing to improved treatment outcomes. The main goal of this study was to validate the content of VRainSUD, a CTP virtual reality-based platform and a mobile follow-up application that proposes to reduce cognitive deficits in SUD. The Delphi method was used to reach a consensus on each of the program’s characteristics (e.g., structure, cognitive training tasks). A panel of experts was invited to participate in the content validation by answering two rounds of questions (scale and free-text boxes) regarding the program. Changes were made between the rounds according to the results of the first round. The consensus was defined as at least 70% of the experts agreeing on the validity of a characteristic. From 39 invited experts, 11 completed the first round, and 6 completed both rounds. The structure of the program reached a consensus on the first round, along with most tasks (with the exception of two mobile application tasks). Significant changes were made following the feedback received, namely turning the program personalizable, and adding positive feedback to the tasks in order to improve adherence and engagement. The Delphi method was a valuable tool to improve VRainSUD. The experts’ opinions validated main features and informed important additional changes, highlighting the importance of expert feedback in the development of cognitive interventions.