Repository logo
 
Publication

Natural approaches for neurological disorders: The neuroprotective potential of Codium tomentosum

2020Journal article Open access
Simple item page
dc.contributor.authorSilva, Joana
dc.contributor.authorMartins, Alice
dc.contributor.authorAlves, Celso
dc.contributor.authorPinteus, Susete
dc.contributor.authorGaspar, Helena
dc.contributor.authorAlfonso, Amparo
dc.contributor.authorPedrosa, Rui
dc.date.accessioned2021-08-20T13:44:32Z
dc.date.available2021-08-20T13:44:32Z
dc.date.issued2020
dc.descriptionFunding: This work was supported by the Portuguese Foundation for Science and Technology (FCT) through the strategic project UID/MAR/04292/2020 to MARE—Marine and Environmental Sciences Centre and UID/Multi/04046/2020 and UIDB/04046/2020 granted to BioISI—BioSystems and Integrative Sciences Institute, through POINT4PAC project (Oncologia de Precisão: Terapias e Tecnologias Inovadoras, SAICTPAC/0019/2015-LISBOA- 01-0145-FEDER-016405), through CROSS-ATLANTIC project (PTDC/BIA-OUT/29250/2017), co-financed by COMPETE (POCI-01-0145-FEDER-029250) and through Molecules for Health project (PTDC/BIA-BQM/28355/2017). This work was also funded by the Integrated Programme of SR&TD Smart Valorization of Endogenous Marine Biological Resources Under a Changing Climate (Centro-01-0145-FEDER-000018), co-funded by Centro 2020 Programme, Portugal 2020, European Union, through the European Regional Development Fund.
dc.descriptionAcknowledgments: The authors are very grateful for the financial support of the Projects and Programmes described in the funding section. FCT is also acknowledged for the grants attributed to JS (SFRH/BD/103255/2014), and SP (SFRH/BD/96203/2013).
dc.description.abstractParkinson’s disease (PD) is the second most common neurodegenerative disorder, and is characterized by a progressive degeneration of the dopaminergic neurons in the substantia nigra. Although not completely understood, several abnormal cellular events are known to be related with PD progression, such as oxidative stress, mitochondrial dysfunction and apoptosis. Accordingly, the aim of this study was to evaluate the neuroprotective e ects of Codium tomentosum enriched fractions in a neurotoxicity model mediated by 6-hydroxydopamine (6-OHDA) on SH-SY5Y human cells, and the disclosure of their mechanisms of action. Additionally, a preliminary chemical screening of the most promising bioactive fractions of C. tomentosum was carried out by GC-MS analysis. Among the tested fractions, four samples exhibited the capacity to revert the neurotoxicity induced by 6-OHDA to values higher or similar to the vitamin E (90.11 +- 3.74% of viable cells). The neuroprotective e ects were mediated by the mitigation of reactive oxygen species (ROS) generation, mitochondrial dysfunctions and DNA damage, together with the reduction of Caspase-3 activity. Compounds belonging to different chemical classes, such as terpenes, alcohols, carboxylic acids, aldehydes, esters, ketones, saturated and unsaturated hydrocarbons were tentatively identified by GC-MS. The results show that C. tomentosum is a relevant source of neuroprotective agents, with particular interest for preventive therapeutics.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, J.; Martins, A.; Alves, C.; Pinteus, S.; Gaspar, H.; Alfonso, A.; Pedrosa, R. Natural Approaches for Neurological Disorders—The Neuroprotective Potential of Codium tomentosum. Molecules 2020, 25, 5478. https://doi.org/10.3390/molecules25225478pt_PT
dc.identifier.doi10.3390/molecules25225478pt_PT
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10400.8/6123
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationUID/MAR/04292/2020pt_PT
dc.relationUID/Multi/04046/2020pt_PT
dc.relationBiosystems and Integrative Sciences Institute
dc.relationNeuroprotective effects of molecules isolated from Bifurcaria bifurcata and Codium tomentosum in an in vitro and in vivo Parkinson Disease model.
dc.relationADD VALUE TO THE MARINE INVADERS ASPARAGOPSIS ARMATA AND SARGASSUM MUTICUM
dc.relation.publisherversionhttps://www.mdpi.com/1420-3049/25/22/5478pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSeaweedpt_PT
dc.subjectMarine natural productspt_PT
dc.subjectNeurodegenerative diseasept_PT
dc.subjectSH-SY5Spt_PT
dc.subjectOxidative stresspt_PT
dc.subjectMitochondrial dysfunctionpt_PT
dc.titleNatural approaches for neurological disorders: The neuroprotective potential of Codium tomentosumpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBiosystems and Integrative Sciences Institute
oaire.awardTitleNeuroprotective effects of molecules isolated from Bifurcaria bifurcata and Codium tomentosum in an in vitro and in vivo Parkinson Disease model.
oaire.awardTitleADD VALUE TO THE MARINE INVADERS ASPARAGOPSIS ARMATA AND SARGASSUM MUTICUM
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04046%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBIA-OUT%2F29250%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-BQM%2F28355%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F103255%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F96203%2F2013/PT
oaire.citation.issue22pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume25pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream9471 - RIDTI
oaire.fundingStream3599-PPCDT
oaire.fundingStreamPOR_CENTRO
oaire.fundingStreamFARH
person.familyNameSilva
person.familyNameMartins
person.familyNameAlves
person.familyNamePinteus
person.familyNameGuerreiro Galla Gaspar
person.familyNameAlfonso Rancaño
person.familyNamePedrosa
person.givenNameJoana
person.givenNameAlice
person.givenNameCelso
person.givenNameSusete
person.givenNameHelena Margarida
person.givenNameMaria Amparo
person.givenNameRui
person.identifier98885
person.identifier159091
person.identifier159292
person.identifierE-6798-2012
person.identifier349272
person.identifier.ciencia-id6317-6F15-BA35
person.identifier.ciencia-idDA19-728A-9BC8
person.identifier.ciencia-id501C-F268-2E60
person.identifier.ciencia-id661E-9677-74C5
person.identifier.ciencia-id761C-044C-995B
person.identifier.ciencia-id2911-AA25-48B7
person.identifier.ciencia-id3817-33DE-919E
person.identifier.orcid0000-0003-1224-1699
person.identifier.orcid0000-0002-0542-2662
person.identifier.orcid0000-0003-1581-2127
person.identifier.orcid0000-0002-3290-3111
person.identifier.orcid0000-0002-1613-7023
person.identifier.orcid0000-0003-1572-9016
person.identifier.orcid0000-0003-0970-0575
person.identifier.ridB-3366-2017
person.identifier.ridB-4815-2015
person.identifier.scopus-author-id56370819800
person.identifier.scopus-author-id56013514200
person.identifier.scopus-author-id55654969100
person.identifier.scopus-author-id55655328300
person.identifier.scopus-author-id7003891380
person.identifier.scopus-author-id7005010300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication23e68f76-0f7a-4f39-9da8-f1a26e2e2cd7
relation.isAuthorOfPublication1bc1a00d-0af9-4be5-b19f-ddaf89268517
relation.isAuthorOfPublicationba5ab7c2-7474-4ea9-9bf0-ca15fe42809a
relation.isAuthorOfPublicationdb45e9a7-9e25-4fbf-903e-9feac4a23d61
relation.isAuthorOfPublication580efc75-e17e-4380-ae50-e5bc1d0bc10d
relation.isAuthorOfPublicationefa7b266-e49a-4a2a-b586-50dc43b43e51
relation.isAuthorOfPublication94496a40-57cf-472f-94e1-5db9d5da78b6
relation.isAuthorOfPublication.latestForDiscovery580efc75-e17e-4380-ae50-e5bc1d0bc10d
relation.isProjectOfPublication67482a6d-1f37-4e55-a5f6-6bf03b067106
relation.isProjectOfPublication26a2e10e-ee41-49ad-9279-4aeaa596b99f
relation.isProjectOfPublication8f1a02df-8822-43d1-9ee8-10d756af0b73
relation.isProjectOfPublication4e599bd2-3733-4520-8d96-9035a23f9e78
relation.isProjectOfPublication53e01013-8879-4bef-8598-cf751d88f28a
relation.isProjectOfPublication.latestForDiscovery8f1a02df-8822-43d1-9ee8-10d756af0b73

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Silva et al_2020_Molecules.pdf
Size:
4 MB
Format:
Adobe Portable Document Format
Description:
Download

Collections

MARE - Artigos com peer review
ESTM - Artigos em revistas internacionais