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A review of conventional and emerging technologies for hydrogels sterilization

2023-02-01Journal article Open access
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dc.contributor.authorS. A. Bento, Cristiana
dc.contributor.authorC. Gaspar, M.
dc.contributor.authorCoimbra, Patrícia
dc.contributor.authorde Sousa, Hermínio C.
dc.contributor.authorE. M. Braga, Mara
dc.date.accessioned2024-01-08T12:19:05Z
dc.date.available2024-01-08T12:19:05Z
dc.date.issued2023-02-01
dc.descriptionFunding This work was financially supported by Fundaçao ˜ para a Ciˆencia e Tecnologia (FCT), Portugal, through the project STERILAEROGEL – Green method to prepare sterilised biopolymer-based aerogel (POCI01–0145-FEDER-032625) and Strategic Projects FCT-MEC PEst-C/EQB/ UI0102/2019, UIDB/00102/2020 and Programmatic Project UIDP/ 00102/2020 of the CIEPQPF, and UI/05704/2020 of the ciTechCare. C. S. A. Bento acknowledges for PhD grant UI/BD/151008/2021 and M. C. Gaspar acknowledges FCT for the financial support under Scientific Employment Stimulus – Individual and Institutional Calls (CEECIND/ 00527/2017 and CEECINST/00060/2021).pt_PT
dc.description.abstractHydrogels are extensively used in the biomedical field, as drug delivery systems, wound dressings, contact lenses or as scaffolds for tissue engineering. Due to their polymeric nature and the presence of high amounts of water in their structure, hydrogels generally present high sensitivity to terminal sterilization. The establishment of an efficient sterilization protocol that does not compromise the functional properties of the hydrogels is one of the challenges faced by researchers when developing a hydrogel for a specific application. Yet, until very recently this aspect was largely ignored in the literature. The present paper reviews the state of literature concerning hydrogels sterilization, compiling the main findings. Conventional terminal sterilization methods (heat sterilization, radiation sterilization, and gas sterilization) as well as emerging sterilization techniques (ozone, supercritical carbon dioxide) are covered. Considerations about aseptic processing are also included. Additionally, and as a framework, hydrogels’ polymeric materials, types of networks, and main biomedical applications are summarily described.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCristiana S. A. Bento, Marisa C. Gaspar, Patrícia Coimbra, Hermínio C. de Sousa, Mara E. M. Braga, A review of conventional and emerging technologies for hydrogels sterilization, International Journal of Pharmaceutics, Volume 634, 2023, 122671, ISSN 0378-5173, https://doi.org/10.1016/j.ijpharm.2023.122671.pt_PT
dc.identifier.doihttps://doi.org/10.1016/j.ijpharm.2023.122671pt_PT
dc.identifier.issn0378-5173
dc.identifier.urihttp://hdl.handle.net/10400.8/9199
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationChemical Process Engineering and Forest Products Research Centre
dc.relationNot Available
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0378517323000911?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectHydrogelpt_PT
dc.subjectPolymerspt_PT
dc.subjectSterilizationpt_PT
dc.subjectAseptic processingpt_PT
dc.subjectBiomedical applicationspt_PT
dc.titleA review of conventional and emerging technologies for hydrogels sterilizationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleChemical Process Engineering and Forest Products Research Centre
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00102%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2ed/CEECINST%2F00060%2F2021%2FCP2799%2FCT0001/PT
oaire.citation.startPage122671pt_PT
oaire.citation.titleInternational Journal of Pharmaceuticspt_PT
oaire.citation.volume634pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC INST 2ed
person.familyNameda Costa Gaspar
person.givenNameMarisa
person.identifier.ciencia-idA71E-6EFA-80FE
person.identifier.orcid0000-0002-5584-6324
person.identifier.scopus-author-id55969188500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8e5c6850-6993-4c60-aa34-7c48037e86d8
relation.isAuthorOfPublication.latestForDiscovery8e5c6850-6993-4c60-aa34-7c48037e86d8
relation.isProjectOfPublicationf52dccbf-8536-4d6a-909e-1f020c237e0d
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