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Marine natural products as anticancer agents 2.0

2023Journal article Open access
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dc.contributor.authorAlves, Celso
dc.contributor.authorDiederich, Marc
dc.date.accessioned2023-09-05T11:19:14Z
dc.date.available2023-09-05T11:19:14Z
dc.date.issued2023
dc.description.abstract[Introduction] Global cancer incidence and death are expected to increase to 28.4 million cases by 2040, despite efforts to understand cancer biology better and to improve its diagnosis and therapy [1]. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes [2]. Over the last few decades, the marine environment has become an important source of molecules with potent anticancer properties, exhibiting unusual chemical features and mechanisms of action. Twelve of seventeen drugs of marine origin approved by regulatory entities are used against cancer, and thirty-four of forty compounds in the marine pharmaceuticals pipeline indicate “cancer therapy” [3].pt_PT
dc.description.sponsorshipMarc Diederich was supported by the National Research Foundation (NRF) by the MEST of Korea for Tumor Microenvironment Global Core Research Center (GCRC) grant (grant number NRF 2011-0030001), by the Seoul National University Research Grant (Funding number: 800-20160150) and by the Creative-Pioneering Researchers Program through Seoul National University (SNU) (Funding number: 370C-20160062). Research at SNU is also supported by the National Research Foundation (NRF) (Grant Number 2022R1A2C101314111). Support from the BrainKorea21 FOUR program is acknowledged. Marc Diederich is supported by the “Recherche Cancer et Sang” foundation, the “Recherches Scientifiques Luxembourg” association, the “Een Häerz fir kriibskrank Kanner” association, the Action LIONS “Vaincre le Cancer” association, and Télévie Luxembourg. C.A. acknowledges the support by the Portuguese Foundation for Science and Technology (FCT) through the Strategic Projects granted to MARE—Marine and Environmental Sciences Centre (UIDP/04292/2020 and UIDB/04292/2020), Associate Laboratory ARNET (LA/P/0069/2020), and through the NEURONS4 (2022.09196.PTDC), MArTics (FCT/DRI/CAPES 2019.00277.CBM) and NEURONS (FCT/DRI/PNAAE 2021.09608.CBM) projects.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlves, C.; Diederich, M. Marine Natural Products as Anticancer Agents 2.0. Mar. Drugs 2023, 21, 247. https://doi.org/10.3390/md21040247pt_PT
dc.identifier.doi10.3390/md21040247pt_PT
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10400.8/8758
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationMarine and Environmental Sciences Centre
dc.relationMarine and Environmental Sciences Centre
dc.relationNew Edge in the therapeUtics of PaRkinsON´s diSeaSe from SeaweedS
dc.relation.publisherversionhttps://www.mdpi.com/1660-3397/21/4/247pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMarine natural productspt_PT
dc.subjectAnticancer agentspt_PT
dc.subjectSemi-synthesispt_PT
dc.subjectMetastasispt_PT
dc.subjectImmunotherapypt_PT
dc.subjectMechanism of actionpt_PT
dc.titleMarine natural products as anticancer agents 2.0pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardTitleNew Edge in the therapeUtics of PaRkinsON´s diSeaSe from SeaweedS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04292%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04292%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/2022.09196.PTDC/PT
oaire.citation.issue4pt_PT
oaire.citation.titleMarine Drugspt_PT
oaire.citation.volume21pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
person.familyNameAlves
person.familyNameDiederich
person.givenNameCelso
person.givenNameMarc
person.identifier159091
person.identifier15709
person.identifier.ciencia-id501C-F268-2E60
person.identifier.orcid0000-0003-1581-2127
person.identifier.orcid0000-0003-0115-4725
person.identifier.ridO-7335-2015
person.identifier.scopus-author-id55654969100
person.identifier.scopus-author-id7003549193
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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