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Phlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Properties

2012Journal article Open access
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dc.contributor.authorFerreres, Federico
dc.contributor.authorLopes, Graciliana
dc.contributor.authorGil-Izquierdo, Angel
dc.contributor.authorAndrade, Paula
dc.contributor.authorSousa, Carla
dc.contributor.authorMouga, Teresa
dc.contributor.authorValentão, Patrícia
dc.date.accessioned2019-09-06T10:36:57Z
dc.date.available2019-09-06T10:36:57Z
dc.date.issued2012
dc.date.updated2019-09-04T14:56:11Z
dc.descriptionThe authors are grateful to Fundação para a Ciência e a Tecnologia (FCT) through grant no. PEst-C/EQB/LA0006/2011, to ―Consolider Ingenio 2010 Project CSD2007-00063 FUN-C-FOOD‖ and to ―Grupo de excelencia de la región de Murcia 04486/GERM/06‖. G. Lopes (SFRH/BD/ 61565/2009) is indebted to FCT, FSE and POPH for the grant.
dc.description.abstractPurified phlorotannin extracts from four brown seaweeds (Cystoseira nodicaulis (Withering) M. Roberts, Cystoseira tamariscifolia (Hudson) Papenfuss, Cystoseira usneoides (Linnaeus) M. Roberts and Fucus spiralis Linnaeus), were characterized by HPLC-DAD-ESI-MSn . Fucophloroethol, fucodiphloroethol, fucotriphloroethol, 7-phloroeckol, phlorofucofuroeckol and bieckol/dieckol were identified. The antioxidant activity and the hyaluronidase (HAase) inhibitory capacity exhibited by the extracts were also assessed. A correlation between the extracts activity and their chemical composition was established. F. spiralis, the species presenting higher molecular weight phlorotannins, generally displayed the strongest lipid peroxidation inhibitory activity (IC50 = 2.32 mg/mL dry weight) and the strongest HAase inhibitory capacity (IC50 = 0.73 mg/mL dry weight). As for superoxide radical scavenging, C. nodicaulis was the most efficient species (IC50 = 0.93 mg/mL dry weight), followed by F. spiralis (IC50 = 1.30 mg/mL dry weight). These results show that purified phlorotannin extracts have potent capabilities for preventing and slowing down the skin aging process, which is mainly associated with free radical damage and with the reduction of hyaluronic acid concentration, characteristic of the process.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerreres, F.; Lopes, G.; Gil-Izquierdo, A.; Andrade, P.B.; Sousa, C.; Mouga, T.; Valentão, P. Phlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Properties. Mar. Drugs 2012, 10, 2766-2781.pt_PT
dc.identifier.doi10.3390/md10122766
dc.identifier.otherWOS:000312607700012
dc.identifier.slugcv-prod-149961
dc.identifier.urihttp://hdl.handle.net/10400.8/4068
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationStrategic Project - LA 6 - 2011-2012
dc.relationMACROALGAE FROM BERLENGAS ARCHIPELAGO AS SOURCE OF BIOACTIVE COMPOUNDS
dc.relation.ispartofMarine Drugsen_US
dc.subjectPhlorotanninspt_PT
dc.subjectSkin agingpt_PT
dc.subjectHyaluronidasept_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectHPLC-DAD-ESI-MSnpt_PT
dc.titlePhlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Propertiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - LA 6 - 2011-2012
oaire.awardTitleMACROALGAE FROM BERLENGAS ARCHIPELAGO AS SOURCE OF BIOACTIVE COMPOUNDS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FEQB%2FLA0006%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F61565%2F2009/PT
oaire.citation.endPage2781pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage2766pt_PT
oaire.citation.titleMarine Drugspt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream6820 - DCRRNI ID
person.familyNameMouga
person.givenNameTeresa
person.identifier.ciencia-idE312-FDCC-1ED8
person.identifier.orcid0000-0003-4849-8840
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaidE312-FDCC-1ED8 | Teresa Mouga
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication901e8c7b-9818-4493-8e96-75d0c5ad718c
relation.isAuthorOfPublication.latestForDiscovery901e8c7b-9818-4493-8e96-75d0c5ad718c
relation.isProjectOfPublication4ef7a632-13d0-492f-ac17-5b6f22236ced
relation.isProjectOfPublicationd41ae0b4-6231-4e6d-b6c0-18923a048c4e
relation.isProjectOfPublication.latestForDiscovery4ef7a632-13d0-492f-ac17-5b6f22236ced

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