Effects of Scaffold Electrical Properties on Electric Field Delivery in Bioreactors

Meneses, João; Fernandes, Sofia R.; Alves, Nuno; Pascoal-Faria, Paula; Miranda, Pedro Cavaleiro

http://hdl.handle.net/10400.8/16202

Utilize este identificador para referenciar este registo.

Nome:	Descrição:	Tamanho:	Formato:
Effects of Scaffold Electrical Properties on Electric Field Delivery in Bioreactors.pdf	In tissue engineering, cell culture scaffolds have been widely used in combination with electrical stimulation to promote multiple cellular outcomes, like differentiation and proliferation. Nevertheless, the influence of scaffolds on the electric field delivered inside a bioreactor is often ignored and requires a deeper study. By performing numerical analysis in a capacitively coupled setup, this work aimed to predict the effects of the scaffold presence on the electric field, considering multiple combinations of scaffold and culture medium electrical properties. We concluded that the effect of the scaffold on the electric field in the surrounding culture medium was determined by the difference in electrical conductivity of these two materials. The numerical simulations pointed to significant variations in local electric field patterns, which could lead to different cellular outcomes and confound the interpretation of the experimental results.	1.81 MB	Adobe PDF	Ver/Abrir

Contacte-nos

Autores

Miranda, Pedro Cavaleiro

Resumo(s)

In tissue engineering, cell culture scaffolds have been widely used in combination with electrical stimulation to promote multiple cellular outcomes, like differentiation and proliferation. Nevertheless, the influence of scaffolds on the electric field delivered inside a bioreactor is often ignored and requires a deeper study. By performing numerical analysis in a capacitively coupled setup, this work aimed to predict the effects of the scaffold presence on the electric field, considering multiple combinations of scaffold and culture medium electrical properties. We concluded that the effect of the scaffold on the electric field in the surrounding culture medium was determined by the difference in electrical conductivity of these two materials. The numerical simulations pointed to significant variations in local electric field patterns, which could lead to different cellular outcomes and confound the interpretation of the experimental results.

Descrição

43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021; Conference date - 1 November 2021 - 5 November 2021; Conference code - 175446
EISBN - 978-172811179-7
Link de acesso ao documento - https://www.researchgate.net/publication/356939492_Effects_of_Scaffold_Electrical_Properties_on_Electric_Field_Delivery_in_Bioreactors

Palavras-chave

Histograms Tissue engineering Electrical stimulation Conductivity Numerical simulation Biology Electric fields

URI

http://hdl.handle.net/10400.8/16202

Citação

J. Meneses, S. R. Fernandes, N. Alves, P. Pascoal-Faria and P. C. Miranda, "Effects of Scaffold Electrical Properties on Electric Field Delivery in Bioreactors," 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Mexico, 2021, pp. 4147-4151, doi: https://doi.org/10.1109/EMBC46164.2021.9630711.