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Effects of Scaffold Electrical Properties on Electric Field Delivery in Bioreactors

2021-11Comunicação em conferência Acesso aberto
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datacite.subject.fosEngenharia e Tecnologia::Engenharia Eletrotécnica, Eletrónica e Informática
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorMeneses, João
dc.contributor.authorFernandes, Sofia R.
dc.contributor.authorAlves, Nuno
dc.contributor.authorPascoal-Faria, Paula
dc.contributor.authorMiranda, Pedro Cavaleiro
dc.date.accessioned2026-04-27T13:31:36Z
dc.date.available2026-04-27T13:31:36Z
dc.date.issued2021-11
dc.description43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021; Conference date - 1 November 2021 - 5 November 2021; Conference code - 175446
dc.descriptionEISBN - 978-172811179-7
dc.descriptionLink de acesso ao documento - https://www.researchgate.net/publication/356939492_Effects_of_Scaffold_Electrical_Properties_on_Electric_Field_Delivery_in_Bioreactors
dc.description.abstractIn tissue engineering, cell culture scaffolds have been widely used in combination with electrical stimulation to promote multiple cellular outcomes, like differentiation and proliferation. Nevertheless, the influence of scaffolds on the electric field delivered inside a bioreactor is often ignored and requires a deeper study. By performing numerical analysis in a capacitively coupled setup, this work aimed to predict the effects of the scaffold presence on the electric field, considering multiple combinations of scaffold and culture medium electrical properties. We concluded that the effect of the scaffold on the electric field in the surrounding culture medium was determined by the difference in electrical conductivity of these two materials. The numerical simulations pointed to significant variations in local electric field patterns, which could lead to different cellular outcomes and confound the interpretation of the experimental results.eng
dc.description.sponsorshipThis research was funded by the Fundação para a Ciência e a Tecnologia (FCT) and Centro2020 through the following Projects: CDRSP UIDP/04044/2020 and and UIDB/04044/2020, PAMI—ROTEIRO/0328/2013 (No 022158); FCT Project Stimuli2BioScaffold ref. PTDC/EMESIS/32554/2017; Bone2Move ref. PTDC/CVT-CVT/31146/2017; MATIS - Ref. CENTRO-01-0145-FEDER-000014-3362; Instituto de Biofísica e Engenharia Biomédica (IBEB) is supported by Fundação para a Ciência e Tecnologia (FCT), Portugal, under Grant UIDB/00645/2020. Also supported by UID/BIO/04565/2020.
dc.identifier.citationJ. Meneses, S. R. Fernandes, N. Alves, P. Pascoal-Faria and P. C. Miranda, "Effects of Scaffold Electrical Properties on Electric Field Delivery in Bioreactors," 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Mexico, 2021, pp. 4147-4151, doi: https://doi.org/10.1109/EMBC46164.2021.9630711.
dc.identifier.doi10.1109/embc46164.2021.9630711
dc.identifier.eissn2694-0604
dc.identifier.isbn978-172811179-7
dc.identifier.isbn978-1-7281-1180-3
dc.identifier.issn2375-7477
dc.identifier.urihttp://hdl.handle.net/10400.8/16202
dc.language.isoeng
dc.peerreviewedyes
dc.publisherIEEE Canada
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationDevelopment of "in vivo" experimental techniques and modeling methodologies for the evaluation of 4D scaffolds on bone defect in sheep model: an integrative research approach.
dc.relationInstitute of biophysics and Biomedical Engineering
dc.relation.hasversionhttps://ieeexplore.ieee.org/document/9630711
dc.relation.ispartof2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
dc.rights.uriN/A
dc.subjectHistograms
dc.subjectTissue engineering
dc.subjectElectrical stimulation
dc.subjectConductivity
dc.subjectNumerical simulation
dc.subjectBiology
dc.subjectElectric fields
dc.titleEffects of Scaffold Electrical Properties on Electric Field Delivery in Bioreactorseng
dc.typeconference paper
dspace.entity.typePublication
oaire.awardNumberUIDP/04044/2020
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oaire.awardNumberPTDC/CVT-CVT/31146/2017
oaire.awardNumberUIDB/00645/2020
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleDevelopment of "in vivo" experimental techniques and modeling methodologies for the evaluation of 4D scaffolds on bone defect in sheep model: an integrative research approach.
oaire.awardTitleInstitute of biophysics and Biomedical Engineering
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04044%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04044%2F2020/PT
oaire.awardURIhttp://hdl.handle.net/10400.8/16201
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00645%2F2020/PT
oaire.citation.conferenceDate2021-11
oaire.citation.conferencePlaceMexico, Mexico
oaire.citation.endPage4151
oaire.citation.startPage4147
oaire.citation.titleAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2017
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
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person.identifier.orcid0000-0002-6920-7152
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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In tissue engineering, cell culture scaffolds have been widely used in combination with electrical stimulation to promote multiple cellular outcomes, like differentiation and proliferation. Nevertheless, the influence of scaffolds on the electric field delivered inside a bioreactor is often ignored and requires a deeper study. By performing numerical analysis in a capacitively coupled setup, this work aimed to predict the effects of the scaffold presence on the electric field, considering multiple combinations of scaffold and culture medium electrical properties. We concluded that the effect of the scaffold on the electric field in the surrounding culture medium was determined by the difference in electrical conductivity of these two materials. The numerical simulations pointed to significant variations in local electric field patterns, which could lead to different cellular outcomes and confound the interpretation of the experimental results.
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