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Publication
Multi-material implants for temporomandibular joint disc repair: Tailored additive manufacturing production
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Advisor(s)
Abstract(s)
Temporomandibular disorders (TMD) affect a substantial percentage of the population, and the resources spent on their treatment are considerable. Despite the worldwide efforts around Tissue Engineering of the temporomandibular joint (TMJ) disc, a proper implant offering a long-term solution for TMD was not yet developed. To contribute to these efforts, this work is focused on the research and development of implants
for TMJ disc regeneration. Scaffolds and hydrogels mimicking the TMJ disc of black Merino sheep were produced using different materials, poly(+-caprolactone) (PCL) and poly(ethylene glycol) diacrylate (PEGDA), and as a multi-material structure. Different parameters of the scaffold manufacturing were assessed: the influence of processing temperatures, filament diameter, and biological environment. Moreover, two multimaterial approaches were also assessed, scaffold with a hydrogel shell and scaffold with a hydrogel core. It was found that increasing temperature, the scaffolds’ porosity decreases, increasing their compressive modulus. Decreasing the filament size (300 to 200 mm) decreases the compressive modulus to almost half of the initial value. Scaffolds with 200 mm filaments are the ones with a closer modulus to the native disc and their
properties are maintained under hydrated conditions. The introduction of a hydrogel core in these scaffolds presented better mechanical properties to TMJ disc substitution.
Description
This work was supported by the Fundação para a Ciência e a Tecnologia (FCT) and Centro2020 through
the Project references: UID/Multi/04044/2019; PAMI – ROTEIRO/0328/2013 (No. 022158),MATIS (CENTRO-01-0145-FEDER-000014 – 3362), and BIODISCUS (CENTRO-01-0247-FEDER-039969).
Keywords
Temporomandibular joint disc, Processing conditions Poly(+-caprolactone) Poly(ethylene glycol) diacrylate Multi-material structures
Pedagogical Context
Citation
Moura C, Trindade D, Vieira M, Francisco L, Ângelo DF and Alves N (2020) Multi-Material Implants for Temporomandibular Joint Disc Repair: Tailored Additive Manufacturing Production. Front. Bioeng. Biotechnol. 8:342. doi: 10.3389/fbioe.2020.00342
Publisher
Frontiers