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Multi-material implants for temporomandibular joint disc repair: Tailored additive manufacturing production

2020Journal article Open access
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dc.contributor.authorMoura, Carla
dc.contributor.authorTrindade, Daniela
dc.contributor.authorVieira, Milena
dc.contributor.authorFrancisco, Luís
dc.contributor.authorÂngelo, David Faustino
dc.contributor.authorAlves, Nuno
dc.date.accessioned2023-04-17T14:08:14Z
dc.date.available2023-04-17T14:08:14Z
dc.date.issued2020
dc.descriptionThis work was supported by the Fundação para a Ciência e a Tecnologia (FCT) and Centro2020 through the Project references: UID/Multi/04044/2019; PAMI – ROTEIRO/0328/2013 (No. 022158),MATIS (CENTRO-01-0145-FEDER-000014 – 3362), and BIODISCUS (CENTRO-01-0247-FEDER-039969).pt_PT
dc.description.abstractTemporomandibular disorders (TMD) affect a substantial percentage of the population, and the resources spent on their treatment are considerable. Despite the worldwide efforts around Tissue Engineering of the temporomandibular joint (TMJ) disc, a proper implant offering a long-term solution for TMD was not yet developed. To contribute to these efforts, this work is focused on the research and development of implants for TMJ disc regeneration. Scaffolds and hydrogels mimicking the TMJ disc of black Merino sheep were produced using different materials, poly(+-caprolactone) (PCL) and poly(ethylene glycol) diacrylate (PEGDA), and as a multi-material structure. Different parameters of the scaffold manufacturing were assessed: the influence of processing temperatures, filament diameter, and biological environment. Moreover, two multimaterial approaches were also assessed, scaffold with a hydrogel shell and scaffold with a hydrogel core. It was found that increasing temperature, the scaffolds’ porosity decreases, increasing their compressive modulus. Decreasing the filament size (300 to 200 mm) decreases the compressive modulus to almost half of the initial value. Scaffolds with 200 mm filaments are the ones with a closer modulus to the native disc and their properties are maintained under hydrated conditions. The introduction of a hydrogel core in these scaffolds presented better mechanical properties to TMJ disc substitution.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMoura C, Trindade D, Vieira M, Francisco L, Ângelo DF and Alves N (2020) Multi-Material Implants for Temporomandibular Joint Disc Repair: Tailored Additive Manufacturing Production. Front. Bioeng. Biotechnol. 8:342. doi: 10.3389/fbioe.2020.00342pt_PT
dc.identifier.doi10.3389/fbioe.2020.00342pt_PT
dc.identifier.issn2296-4185
dc.identifier.urihttp://hdl.handle.net/10400.8/8395
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationCentre for Rapid and Sustainable Product Development
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fbioe.2020.00342/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectTemporomandibular joint disc,pt_PT
dc.subjectProcessing conditionspt_PT
dc.subjectPoly(+-caprolactone)pt_PT
dc.subjectPoly(ethylene glycol) diacrylatept_PT
dc.subjectMulti-material structurespt_PT
dc.titleMulti-material implants for temporomandibular joint disc repair: Tailored additive manufacturing productionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04044%2F2019/PT
oaire.citation.titleFrontiers in Bioengineering and Biotechnologypt_PT
oaire.citation.volume8pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMonteiro de Moura
person.familyNameTrindade
person.familyNameVieira
person.familyNameAlves
person.givenNameCarla Sofia
person.givenNameDaniela Alexandra
person.givenNameMilena
person.givenNameNuno
person.identifier452149
person.identifier.ciencia-id671C-8FEC-A14A
person.identifier.ciencia-id6316-1507-A39A
person.identifier.ciencia-id3518-08C5-CBC6
person.identifier.ciencia-id311E-1559-8F6C
person.identifier.orcid0000-0003-2610-1005
person.identifier.orcid0000-0003-3621-7095
person.identifier.orcid0000-0002-2376-6557
person.identifier.orcid0000-0002-5016-0868
person.identifier.ridN-4073-2013
person.identifier.scopus-author-id7006403383
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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