CBmeter study: Protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases

Lages, Marlene; Carvalho, Lucinda; Feijó, Salvato; Vieira, Alexandra; Fonseca-Pinto, Rui; Guarino, Maria Pedro

http://hdl.handle.net/10400.8/7128

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Authors

Lages, Marlene

Carvalho, Lucinda

Feijó, Salvato

Vieira, Alexandra

Fonseca-Pinto, Rui

Guarino, Maria Pedro

Abstract(s)

Early screening of metabolic diseases is crucial since continued undiagnostic places an ever-increasing burden on healthcare systems. Recent studies suggest a link between overactivated carotid bodies (CB) and the genesis of type 2 diabetes mellitus. The non-invasive assessment of CB activity by measuring ventilatory, cardiac and metabolic responses to challenge tests may have predictive value for metabolic diseases; however, there are no commercially available devices that assess CB activity. The findings of the CBmeter study will clarify the role of the CBs in the genesis of—metabolic diseases and guide the development of new therapeutic approaches for early intervention in metabolic disturbances. Results may also contribute to patient classification and stratification for future CB modulatory interventions.

URI

http://hdl.handle.net/10400.8/7128

Citation

Lages M, Carvalho L, Feijó S, et al. CBmeter study: protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases. BMJ Open 2021;11:e042825. doi:10.1136/ bmjopen-2020-042825