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Physical exercise positively modulates nonalcoholic steatohepatitis‐related hepatic endoplasmic reticulum stress

2022Journal article Restricted access
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dc.contributor.authorPassos, Emanuel
dc.contributor.authorPereira, Cidália
dc.contributor.authorGonçalves, Inês O.
dc.contributor.authorFaria, Ana
dc.contributor.authorAscensão, António
dc.contributor.authorMonteiro, Rosário
dc.contributor.authorMagalhães, José
dc.contributor.authorMartins, Maria J.
dc.date.accessioned2023-07-03T16:08:45Z
dc.date.available2023-07-03T16:08:45Z
dc.date.issued2022
dc.descriptionFunding information: PEst‐OE/SAU/UI0038/2014 to Department of Biochemistry (U38/FCT) of Faculty of Medicine, Grant/Award Number: FCT grant; PEst‐OE/SAU/UI0617/2011 and PTDC/DTP‐DES/7087/2014‐POCI‐01‐0145‐FEDER‐ 016690 to CIAFEL, Grant/Award Number: FCT Grant; SFRH/BDE/33798/2009 to CP, Grant/Award Number: FCT grant; SFRH/BD/71149/2010 to EP, Grant/Award Number: FCT grantpt_PT
dc.description.abstractObesity is a predictive factor for the development of nonalcoholic steatohepatitis (NASH). Although some of the mechanisms associated with NASH development are still elusive, its pathogenesis relies on a complex broad spectrum of (interconnected) metabolic-based disorders. We analyzed the effects of voluntary physical activity (VPA) and endurance training (ET), as preventive and therapeutic nonpharmacological strategies, respectively, against hepatic endoplasmic reticulum (ER) stress, ER-related proapoptotic signaling, and oxidative stress in an animal model of high-fat diet (HFD)-induced NASH. Adult male Sprague-Dawley rats were divided into standard control liquid diet (SCLD) or HFD groups, with sedentary, VPA, and ET subgroups in both (sedentary animals with access to SCLD [SS], voluntarily physically active animals with access to SCLD [SV], and endurance-trained animals with access to SCLD [ST] in the former and sedentary animals with access to liquid HFD [HS], voluntarily physically active animals with access to liquid HFD [HV], and endurance-trained animals with access to liquid HFD [HT] in the latter, respectively). Hepatic ER stress and ER-related proapoptotic signaling were evaluated by Western blot and reverse transcriptase-polymerase chain reaction; redox status was evaluated through quantification of lipid peroxidation, protein carbonyls groups, and glutathione levels as well as antioxidant enzymes activity. In SCLD-treated animals, VPA significantly decreased eukaryotic initiation factor-2 alpha (eIF2α). In HFD-treated animals, VPA significantly decreased eIF2α and phospho-inositol requiring enzyme-1 alpha (IRE1α) but ET significantly decreased eIF2α and significantly increased both spliced X-box binding protein 1 (sXBP1) and unspliced X-box binding protein 1; a significant increase of phosphorylated-eIF2α (p-eIF2α) to eIF2α ratio occurred in ET versus VPA. HS compared to SS disclosed a significant increase of total and reduced glutathione, HV compared to SV a significant increase of oxidized glutathione, HT compared to ST a significant increase of p-eIF2α to eIF2α ratio and sXBP1. Physical exercise counteracts NASH-related ER stress and its associated deleterious consequences through a positive and dynamical modulation of the hepatic IRE1α-X-box binding protein 1 pathway.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPassos, E, Pereira, C, Gonçalves, IO, et al. Physical exercise positively modulates nonalcoholic steatohepatitis-related hepatic endoplasmic reticulum stress. J Cell Biochem. 2022; 123: 1647- 1662. doi:10.1002/jcb.30250pt_PT
dc.identifier.doihttps://doi.org/10.1002/jcb.30250pt_PT
dc.identifier.eissn1097-4644
dc.identifier.issn0730-2312
dc.identifier.pmid35467032
dc.identifier.urihttp://hdl.handle.net/10400.8/8657
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJournal of Cellular Biochemistrypt_PT
dc.relationStrategic Project - UI 38 - 2014
dc.relationOBESITY AND METABOLIC SYNDROME : AMELIORATION OF ASSOCIATED WESTER DIET THROUGH SOME BEVERAGES AND NUTRIENTS
dc.relationEXERCISE AND STATINS. INVESTIGATING THE ROLE OF DAILY PHYSICAL ACTIVITY AND AEROBIC FITNESS ON STATINS TREATMENT-INDUCED MUSCLE DYSFUNCTION
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1002/jcb.30250#pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCell deathpt_PT
dc.subjectNonalcoholic steatohepatitispt_PT
dc.subjectOxidative stresspt_PT
dc.subjectPhysical exercisept_PT
dc.subjectUnfolded protein responsept_PT
dc.titlePhysical exercise positively modulates nonalcoholic steatohepatitis‐related hepatic endoplasmic reticulum stresspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 38 - 2014
oaire.awardTitleOBESITY AND METABOLIC SYNDROME : AMELIORATION OF ASSOCIATED WESTER DIET THROUGH SOME BEVERAGES AND NUTRIENTS
oaire.awardTitleEXERCISE AND STATINS. INVESTIGATING THE ROLE OF DAILY PHYSICAL ACTIVITY AND AEROBIC FITNESS ON STATINS TREATMENT-INDUCED MUSCLE DYSFUNCTION
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FSAU%2FUI0038%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBDE%2F33798%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F71149%2F2010/PT
oaire.citation.endPage1662pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage1647pt_PT
oaire.citation.titleJournal of Cellular Biochemistrypt_PT
oaire.citation.volume123pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamFARH
oaire.fundingStreamFARH
person.familyNamePereira
person.givenNameCidália Almeida
person.identifier.ciencia-idAC15-8934-CC03
person.identifier.orcid0000-0001-9934-9648
person.identifier.ridGPP-6411-2022
person.identifier.scopus-author-id56016000600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa4dd40ab-92e7-42e2-8a47-99f2f3879b89
relation.isAuthorOfPublication.latestForDiscoverya4dd40ab-92e7-42e2-8a47-99f2f3879b89
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