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Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca

2022Journal article Open access
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dc.contributor.authorFeijão, Eduardo
dc.contributor.authorCarvalho, Ricardo Cruz de
dc.contributor.authorDuarte, Irina A.
dc.contributor.authorMatos, Ana Rita
dc.contributor.authorCabrita, Maria Teresa
dc.contributor.authorUtkin, Andrei B.
dc.contributor.authorCaçador, Isabel
dc.contributor.authorMarques, João Carlos
dc.contributor.authorNovais, Sara C.
dc.contributor.authorLemos, Marco F.L.
dc.contributor.authorReis-Santos, Patrick
dc.contributor.authorFonseca, Vanessa
dc.contributor.authorDuarte, Bernardo
dc.date.accessioned2023-08-24T11:18:06Z
dc.date.available2023-08-24T11:18:06Z
dc.date.issued2022
dc.descriptionThe authors would like to thank Fundação para a Ciência e a Tecnologia (FCT) for funding the research at MARE (UIDB/04292/2020 and UIDP/04292/2020), ARNET-Aquatic Research Infrastructure Network Associated Laboratory (LA/P/0069/2020), BioISI (UID/MULTI/04046/2019) and via project grant PTDC/CTA-AMB/30056/2017 (OPTOX). Work was also funded by the Integrated Programme of SR&TD SmartBioR (reference Centro-01-0145-FEDER-000018), co-funded by Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fund. BD and VF were supported by researcher contracts (CEEC-IND/00511/2017 and 2021.00244.CEECIND). MC and SN is supported by a DL-57 investigation contract.pt_PT
dc.description.abstractEmerging pollutants impose a high degree of stress on marine ecosystems, compromising valuable resources, the planet and human health. Pharmaceutical residues often reachmarine ecosystems, and their input is directly related to human activities. Fluoxetine is an antidepressant, and one of the most prescribed selective serotonin reuptake inhibitors globally and has been detected in aquatic ecosystems in concentrations up to 40 μg L−1. The present study aims to evaluate the impact of fluoxetine ecotoxicity on the photochemistry, energy metabolism and enzyme activity of Ulva lactuca exposed to environmentally relevant concentrations (0.3, 0.6, 20, 40, and 80 μg L−1). Exogenous fluoxetine exposure induced negative impacts on U. lactuca photochemistry, namely on photosystem II antennae grouping and energy fluxes. These impacts included increased oxidative stress and elevated enzymatic activity of ascorbate peroxidase and glutathione reductase. Lipid content increased and the altered levels of key fatty acids such as hexadecadienoic (C16:2) and linoleic (C18:2) acids revealed strong correlations with fluoxetine concentrations tested. Multivariate analyses reinforced the oxidative stress and chlorophyll a fluorescence-derived traits as efficient biomarkers for future toxicology studies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFeijão E, Cruz de Carvalho R, Duarte IA, Matos AR, Cabrita MT, Utkin AB, Caçador I, Marques JC, Novais SC, Lemos MFL, Reis-Santos P, Fonseca VF and Duarte B (2022), Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca. Front. Environ. Sci. 10:963537. doi: 10.3389/fenvs.2022.963537pt_PT
dc.identifier.doi10.3389/fenvs.2022.963537pt_PT
dc.identifier.issn2296-665X
dc.identifier.urihttp://hdl.handle.net/10400.8/8729
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationMarine and Environmental Sciences Centre
dc.relationMarine and Environmental Sciences Centre
dc.relationBiosystems & Integrative Sciences Institute
dc.relationDevelopment and validation of bio-optical ecotoxicological tests in marine phototrophs.
dc.relationSeaCODE - Seafood provenance and traceability tool development towards sustainable fisheries with science-based solutions
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fenvs.2022.963537/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntidepressantspt_PT
dc.subjectMacroalgaept_PT
dc.subjectOxidative stresspt_PT
dc.subjectPharmaceuticalspt_PT
dc.subjectPhotobiologypt_PT
dc.titleFluoxetine induces photochemistry-derived oxidative stress on Ulva lactucapt_PT
dc.typejournal article
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oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardTitleBiosystems & Integrative Sciences Institute
oaire.awardTitleDevelopment and validation of bio-optical ecotoxicological tests in marine phototrophs.
oaire.awardTitleSeaCODE - Seafood provenance and traceability tool development towards sustainable fisheries with science-based solutions
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oaire.citation.titleFrontiers in Environmental Sciencept_PT
oaire.citation.volume10pt_PT
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