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Recent Advances in Additive Biomanufacturing

2014Book part Open access
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datacite.subject.fosEngenharia e Tecnologia::Outras Engenharias e Tecnologias
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorPereira, Rúben Filipe Brás
dc.contributor.authorBartolo, Paulo
dc.date.accessioned2025-06-25T14:09:08Z
dc.date.available2025-06-25T14:09:08Z
dc.date.issued2014
dc.descriptionDisponível apenas o Abstract (colocado em Open Access).
dc.description.abstractThe principles of tissue engineering and regenerative medicine have been used for the development of innovative medical therapies for engineering tissues and organs. These therapies involve the use of biomaterials, cells, and biologically active molecules, according to two fundamental strategies: the top-down and bottom-up approaches. Top-down approaches, which are the most commonly used, involve the implantation of porous scaffolds, with or without living cells and bioactive agents, into the defect site in the patient. In these approaches, scaffolds act as temporary templates for the seeded cells, mimicking the properties of the native extracellular matrix and providing an adequate environment for the growth of the new tissue. Scaffolds can be produced by using either conventional or additive techniques, resulting in structures with different levels of porosity, pore size, interconnectivity, and spatial distribution. Additive biomanufacturing techniques allow significantly more control over the scaffold characteristics (e.g., architecture, porosity, permeability, etc.), enabling the automatic and reproducible fabrication of scaffolds in a wide range of polymeric, ceramic, and composite materials. Some of these techniques also allow the fabrication of constructs encapsulating living cells. This chapter describes the most recent advances in the top-down approach to fabricate scaffolds for tissue regeneration, presenting the most important additive biomanufacturing techniques and processable materials. Future perspectives in the field and challenges for future research are also discussed.eng
dc.identifier.citationR.F. Pereira, P.J. Bártolo, 10.10 - Recent Advances in Additive Biomanufacturing, Editor(s): Saleem Hashmi, Gilmar Ferreira Batalha, Chester J. Van Tyne, Bekir Yilbas, Comprehensive Materials Processing, Elsevier, 2014, Pages 265-284, ISBN 9780080965338, https://doi.org/10.1016/B978-0-08-096532-1.01009-8.
dc.identifier.doi10.1016/b978-0-08-096532-1.01009-8
dc.identifier.isbn9780080965338
dc.identifier.isbn978-008096532-1
dc.identifier.urihttp://hdl.handle.net/10400.8/13418
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/abs/pii/B9780080965321010098?via%3Dihub
dc.relation.ispartofComprehensive Materials Processing
dc.rights.uriN/A
dc.subjectAdditive biomanufacturing
dc.subjectExtrusion-based processes
dc.subjectIn situ biomanufacturing
dc.subjectInkjet printing processes
dc.subjectScaffold
dc.subjectSelective laser sintering
dc.subjectTissue engineering
dc.subjectTop-down approach
dc.subjectVat photopolymerization
dc.titleRecent Advances in Additive Biomanufacturingeng
dc.typebook part
dspace.entity.typePublication
oaire.citation.endPage284
oaire.citation.startPage265
oaire.citation.titleComprehensive Materials Processing
oaire.citation.volume10
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameBrás Pereira
person.familyNameBartolo
person.givenNameRúben Filipe
person.givenNamePaulo
person.identifier1337969
person.identifier203086
person.identifier.ciencia-id9417-153E-4473
person.identifier.ciencia-id5810-9BF9-4522
person.identifier.orcid0000-0002-7255-3400
person.identifier.orcid0000-0003-3683-726X
person.identifier.ridP-8503-2018
person.identifier.ridF-2421-2013
person.identifier.scopus-author-id55421048100
person.identifier.scopus-author-id6603353041
relation.isAuthorOfPublicationeda35774-59b3-4801-aa88-9c20f4c31a78
relation.isAuthorOfPublicationab44d1ae-46d0-45c2-b19f-200024b5a990
relation.isAuthorOfPublication.latestForDiscoveryeda35774-59b3-4801-aa88-9c20f4c31a78

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The principles of tissue engineering and regenerative medicine have been used for the development of innovative medical therapies for engineering tissues and organs. These therapies involve the use of biomaterials, cells, and biologically active molecules, according to two fundamental strategies: the top-down and bottom-up approaches. Top-down approaches, which are the most commonly used, involve the implantation of porous scaffolds, with or without living cells and bioactive agents, into the defect site in the patient. In these approaches, scaffolds act as temporary templates for the seeded cells, mimicking the properties of the native extracellular matrix and providing an adequate environment for the growth of the new tissue. Scaffolds can be produced by using either conventional or additive techniques, resulting in structures with different levels of porosity, pore size, interconnectivity, and spatial distribution. Additive biomanufacturing techniques allow significantly more control over the scaffold characteristics (e.g., architecture, porosity, permeability, etc.), enabling the automatic and reproducible fabrication of scaffolds in a wide range of polymeric, ceramic, and composite materials. Some of these techniques also allow the fabrication of constructs encapsulating living cells. This chapter describes the most recent advances in the top-down approach to fabricate scaffolds for tissue regeneration, presenting the most important additive biomanufacturing techniques and processable materials. Future perspectives in the field and challenges for future research are also discussed.
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