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Saccorhiza polyschides: A source of natural active ingredients for greener skincare formulations

2022Journal article Open access
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dc.contributor.authorSusano, Patrícia
dc.contributor.authorSilva, Joana
dc.contributor.authorAlves, Celso
dc.contributor.authorMartins, Alice
dc.contributor.authorPinteus, Susete
dc.contributor.authorGaspar, Helena
dc.contributor.authorGoettert, Márcia Inês
dc.contributor.authorPedrosa, Rui
dc.date.accessioned2023-09-04T13:16:54Z
dc.date.available2023-09-04T13:16:54Z
dc.date.issued2022
dc.descriptionThis work was funded by the Portuguese Foundation for Science and Technology (FCT) through the strategic projects granted to the MARE—Marine and Environmental Sciences Centre (UIDP/04292/2020; UIDB/04292/2020), BioISI—BioSystems and Integrative Sciences Institute (UIDP/Multi/04046/2020; UIDB/04046/2020), and Associate Laboratory ARNET (LA/P/0069/2020). FCT also supported this study through the CROSS-ATLANTIC project (PTDC/BIA-OUT/29250/2017), co-financed by COMPETE (PO-CI-01-0145-FEDER-029250). This work was also supported by the FCT and CAPES cooperation agreement through project MArTics (FCT/DRI/CAPES 2019.00277.CBM). It was also funded by the National NMR Network (PTNMR), partially supported by Infrastructure Project Nº 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC.pt_PT
dc.description.abstractThe growing knowledge about the harmful effects caused by some synthetic ingredients present in skincare products has led to an extensive search for natural bioactives. Thus, this study aimed to investigate the dermatological potential of five fractions (F1–F5), obtained by a sequential extraction procedure, from the brown seaweed Saccorhiza polyschides. The antioxidant (DPPH, FRAP, ORAC and TPC), anti-enzymatic (collagenase, elastase, hyaluronidase and tyrosinase), antimicrobial (Staphylococcus epidermidis, Cutibacterium acnes and Malassezia furfur), anti-inflammatory (nitric oxide, tumor necrosis factor-α, interleukin-6 and interleukin-10) and photoprotective (reactive oxygen species) properties of all fractions were evaluated. The ethyl acetate fraction (F3) displayed the highest antioxidant and photoprotective capacity, reducing ROS levels in UVA/B-exposed 3T3 fibroblasts, and the highest anti-enzymatic capacity against tyrosinase (IC50 value: 89.1 µg/mL). The solid water-insoluble fraction (F5) revealed the greatest antimicrobial activity against C. acnes growth (IC50 value: 12.4 µg/mL). Furthermore, all fractions demonstrated anti-inflammatory potential, reducing TNF-α and IL-6 levels in RAW 264.7 macrophages induced with lipopolysaccharides. Chemical analysis of the S. polyschides fractions by NMR revealed the presence of different classes of compounds, including lipids, polyphenols and sugars. The results highlight the potential of S. polyschides to be incorporated into new nature-based skincare products.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSusano, P.; Silva, J.; Alves, C.; Martins, A.; Pinteus, S.; Gaspar, H.; Goettert, M.I.; Pedrosa, R. Saccorhiza polyschides—A Source of Natural Active Ingredients for Greener Skincare Formulations. Molecules 2022, 27, 6496. https:// doi.org/10.3390/molecules27196496pt_PT
dc.identifier.doi10.3390/molecules27196496pt_PT
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10400.8/8755
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationMarine and Environmental Sciences Centre
dc.relationMarine and Environmental Sciences Centre
dc.relationBiosystems and Integrative Sciences Institute
dc.relation.publisherversionhttps://www.mdpi.com/1420-3049/27/19/6496pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBioactive compoundspt_PT
dc.subjectBrown macroalgaept_PT
dc.subjectDermatological potentialpt_PT
dc.subjectOxidative stresspt_PT
dc.subjectAnti-inflammatory activitypt_PT
dc.titleSaccorhiza polyschides: A source of natural active ingredients for greener skincare formulationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardTitleBiosystems and Integrative Sciences Institute
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04292%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04292%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04046%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBIA-OUT%2F29250%2F2017/PT
oaire.citation.issue19pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume27pt_PT
oaire.fundingStream6817 - DCRRNI ID
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person.familyNameFrederico Susano
person.familyNameSilva
person.familyNameAlves
person.familyNameMartins
person.familyNamePinteus
person.familyNameGuerreiro Galla Gaspar
person.familyNameGoettert
person.familyNamePedrosa
person.givenNamePatrícia
person.givenNameJoana
person.givenNameCelso
person.givenNameAlice
person.givenNameSusete
person.givenNameHelena Margarida
person.givenNameMárcia Inês
person.givenNameRui
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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rcaap.typearticlept_PT
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