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Immunological parameters in burns

2006-11Conference object Open access
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dc.contributor.authorCardoso, Susana
dc.contributor.authorCabral, Luis
dc.contributor.authorCruzeiro, Celso
dc.contributor.authorGarção, Fátima
dc.contributor.authorSantos Rosa, Manuel
dc.date.accessioned2020-09-25T15:34:00Z
dc.date.available2020-09-25T15:34:00Z
dc.date.issued2006-11
dc.description.abstractIntroduction: The activation of a pro-inflammatory cascade induced by burn injury seems to be an important mechanism in the development of sepsis and multiple organ failure. Most studies refer to a deregulation of macrophages activity and changes of cytokines Th1/Th2. However, there is no pattern evolution for the various situations. Methods: For this preliminary and exploratory prospective study, we intend to select about 20-30 patients, from the age of 25 to 50, second and third degree burnt, more than 20% TBSA (total burned surface area) and interior to 60%. All these patients are submitted to balneotherapy and surgical treatment (grafting). The analysed parameters are the cytokines IL-6, IL-8, IL-10, IL-12 and complement. The monitoring is initiated very precociously (immediately after admission) and repeated three days after and with one week intervals. Samples can eventually be collected when clinical report justifies. Results and Conclusion: The aim of our study is to give an overview about immunological alterations in severely burned patients, correlating with burned area, gender, post-burn evolution and fatality in order to identify prognostic indicators. Thus, the present study and more comprehensive understanding of the phenomena will hopefully provide a precocious detection of the more serious situations. A small group of patients are submitted to IVIG treatment to investigate the utility of this therapeutic strategy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCardoso, S., Cabral, L., Cruzeiro, C., Garção, F. & Rosa, M. (2005). Immunological parameters in burns: prognostic indicators and intravenous immunoglobulins influence. [Poster presentation]. V Congresso de Investigação em Medicina, Coimbra, Portugal, 23-24 Novembropt_PT
dc.identifier.urihttp://hdl.handle.net/10400.8/5147
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectBurned patientspt_PT
dc.subjectImmunological parameterspt_PT
dc.titleImmunological parameters in burnspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.titleV Congresso de Investigação em Medicina, Coimbra, Portugal, 23-24 Novembro, 2006pt_PT
person.familyNameCardoso
person.givenNameSusana
person.identifier.orcid0000-0003-1994-6958
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication73ed45a1-7a26-4857-9784-d4f5212e44da
relation.isAuthorOfPublication.latestForDiscovery73ed45a1-7a26-4857-9784-d4f5212e44da

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