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Immunological parameters in burns
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Advisor(s)
Abstract(s)
Introduction: The activation of a pro-inflammatory cascade induced by burn injury seems to be an important mechanism in the development of sepsis and multiple organ failure. Most studies refer to a deregulation of macrophages activity and changes of cytokines Th1/Th2. However, there is no pattern evolution for the various situations.
Methods: For this preliminary and exploratory prospective study, we intend to select about 20-30 patients, from the age of 25 to 50, second and third degree burnt, more than 20% TBSA (total burned surface area) and interior to 60%. All these patients are submitted to balneotherapy and surgical treatment (grafting).
The analysed parameters are the cytokines IL-6, IL-8, IL-10, IL-12 and complement. The monitoring is initiated very precociously (immediately after admission) and repeated three days after and with one week intervals. Samples can eventually be collected when clinical report justifies.
Results and Conclusion: The aim of our study is to give an overview about immunological alterations in severely burned patients, correlating with burned area, gender, post-burn evolution and fatality in order to identify prognostic indicators. Thus, the present study and more comprehensive understanding of the phenomena will hopefully provide a precocious detection of the more serious situations. A small group of patients are submitted to IVIG treatment to investigate the utility of this therapeutic strategy.
Description
Keywords
Burned patients Immunological parameters
Citation
Cardoso, S., Cabral, L., Cruzeiro, C., Garção, F. & Rosa, M. (2005). Immunological parameters in burns: prognostic indicators and intravenous immunoglobulins influence. [Poster presentation]. V Congresso de Investigação em Medicina, Coimbra, Portugal, 23-24 Novembro