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Association between dietary intake and the expression of clock genes in adults: a brief report

2025-10-08Journal article Open access
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorLages, Marlene
dc.contributor.authorBarros, Renata
dc.contributor.authorFerreira-Marques, Marisa
dc.contributor.authorCorreia, Joana
dc.contributor.authorCaseiro, Armando
dc.contributor.authorGuarino, Maria P.
dc.contributor.authorCarmo Silva, Sara
dc.contributor.editorLe Coutre, Johannes
dc.date.accessioned2025-11-27T15:56:04Z
dc.date.available2025-11-27T15:56:04Z
dc.date.issued2025-10-08
dc.descriptionThe authors would like to thank the nursing staff for their valuable assistance with blood sample collection and the undergraduate students from the Bachelor’s in Dietetics and Nutrition, School of Health Sciences, Polytechnic University of Leiria and from the Bachelor in Biomedical Laboratory Sciences, Coimbra Health School, Polytechnic University of Coimbra, for their dedicated support in data collection.
dc.descriptionArticle number - 1663559
dc.description.abstractBackground: The circadian system regulates several physiological processes, including energy metabolism, through the expression of core clock genes. Animal studies suggest that dietary composition can influence circadian gene expression; however, evidence in humans remains limited. Objective: This study aimed to explore the association between dietary macronutrient intake and the expression of circadian clock genes in the whole blood of adults with distinct metabolic profiles. Methods: Nineteen adults (94.7% female; 43.4 ± 16.05 years) were categorized into healthy-weight and overweight/obesity groups based on BMI. Dietary intake was assessed using a 3-day food diary, and clock gene expression (CLOCK, BMAL1, PER2, CRY) was evaluated in whole blood samples collected between 08:00 a.m. and 04:00 p.m. Statistical analyses included group comparisons and correlation analyses between macronutrient intake and gene expression. Results: No statistically significant differences were observed in the clock gene expression between BMI groups, although group-level trends were noted, particularly in PER2 and CRY expression. The overweight/obesity group exhibited a significantly higher percentage of energy intake from protein. Correlation analyses revealed several time-dependent associations between macronutrient intake and clock gene expression. Notably, in the healthy BMI group, BMAL1 and CRY expression correlated with lipid and protein intake, while in the overweight/obesity group, CLOCK expression was strongly associated with both lipid and carbohydrate intake. Conclusion: These findings suggest that macronutrient composition may influence peripheral circadian gene expression in a time- and BMI-dependent manner. Further research is necessary to confirm these associations in larger and more diverse populations and to investigate the potential for chrononutrition strategies to support metabolic health.eng
dc.description.sponsorshipThe author(s) declare that financial support was received for the research and/or publication of this article. This study was supported by Portuguese national funds provided by FCT—Fundação para a Ciência e Tecnologia, I.P. (UID/05704/2023), by the Portuguese Society of Diabetology (Sociedade Portuguesa de Diabetologia) through the award of the 2020 Emilio Peres Scholarship and by the Faculty of Nutrition and Food Sciences of the University of Porto and LabITR (LA/P/0064/2020). ML is supported by a PhD Scholarship from FCT—Fundação para a Ciência e Tecnologia, I.P. (10.54499/2021.07673.BD). MPG work is funded by national funds through FCT—Fundação para a Ciência e Tecnologia, I.P., under the Scientific Employment Stimulus-Institutional Call (10.54499/CEECINST/00051/2018/CP1566/CT0009).
dc.identifier.citationLages M, Barros R, Ferreira-Marques M, Correia J, Caseiro A, Guarino MP and Carmo-Silva S (2025) Association between dietary intake and the expression of clock genes in adults: a brief report. Front. Nutr. 12:1663559. doi: 10.3389/fnut.2025.1663559
dc.identifier.doi10.3389/fnut.2025.1663559
dc.identifier.eissn2296-861X
dc.identifier.issn2296-861X
dc.identifier.urihttp://hdl.handle.net/10400.8/14758
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFrontiers Media
dc.relationLaboratory for Integrative and Translational Research in Population Health
dc.relationNutriClock: Understanding the association between chronotype and metabolic homeostasis: the circadian clock as a tool for nutritional intervention in obesity
dc.relation.hasversionhttps://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1663559/full
dc.relation.ispartofFrontiers in Nutrition
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectChrononutrition
dc.subjectCircadian
dc.subjectClock genes
dc.subjectDiet
dc.subjectObesity
dc.titleAssociation between dietary intake and the expression of clock genes in adults: a brief reporteng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleLaboratory for Integrative and Translational Research in Population Health
oaire.awardTitleNutriClock: Understanding the association between chronotype and metabolic homeostasis: the circadian clock as a tool for nutritional intervention in obesity
oaire.awardURIhttp://hdl.handle.net/10400.8/14186
oaire.awardURIhttp://hdl.handle.net/10400.8/14300
oaire.citation.titleFrontiers in Nutrition
oaire.citation.volume12
oaire.fundingStreamConcurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLages
person.familyNameGuarino
person.familyNameCarmo Silva
person.givenNameMarlene
person.givenNameMaria Pedro
person.givenNameSara
person.identifier.ciencia-idC613-4639-10A8
person.identifier.ciencia-idF21A-BD01-2D52
person.identifier.orcid0000-0002-7389-6368
person.identifier.orcid0000-0001-6079-1105
person.identifier.orcid0000-0001-6124-0428
person.identifier.ridB-5594-2015
person.identifier.scopus-author-id56348477000
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relation.isProjectOfPublication2975499f-0aba-422c-9c56-28058cb61756
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