Highlighting the biological potential of the brown seaweed Fucus spiralis for skin applications

Skin aging is a biological process influenced by intrinsic and extrinsic factors. The last ones, mainly exposure to UV radiation, increases reactive oxygen species (ROS) production leading to a loss of extracellular matrix, also enhanced by enzymatic degradation of matrix supporting molecules. Thus, and with the growing demand for eco-friendly skin products, natural compounds extracted from brown seaweeds revealed to be good candidates due to their broad range of bioactivities, especially as antioxidants. The aim of this study was to assess the dermo-cosmetic potential of di erent fractions obtained from the brown seaweed Fucus spiralis. For this purpose, in vitro antioxidant (Total Phenolic Content (TPC), 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, Ferric Reducing Antioxidant Power (FRAP), Oxygen Radical Absorbance Capacity (ORAC)), anti-enzymatic (collagenase, elastase and hyaluronidase), antimicrobial, anti-inflammatory (NO production) and photoprotective (ROS production) capacities were evaluated. Although nearly all fractions evidenced antioxidant e ects, fraction F10 demonstrated the highest antioxidant ability (EC50 of 38.5 g/mL, DPPH assay), and exhibited a strong e ect as an inhibitor of collagenase (0.037 g/mL) and elastase (3.0 g/mL). Moreover, this fraction was also the most potent on reducing ROS production promoted by H2O2 (IC50 of 41.3 g/mL) and by UVB (IC50 of 31.3 g/mL). These bioactivities can be attributed to its high content of phlorotannins, as evaluated by LC-MS analysis, reinforcing the potential of F. spiralis for further dermatological applications.

Description

Funding: This work was supported by the Portuguese Foundation for Science and Technology (FCT) through the strategic project UID/MAR/04292/2020 granted to MARE—Marine and Environmental Sciences Centre, through Red2Discovery project (PTDC/MAR-BIO/6149/2014), co-financed by COMPETE (POCI-01-0145-FEDER-016791), through Oncologia de Precisão: Terapias e Tecnologias Inovadoras project (POINT4PAC) (SAICTPAC/0019/2015-LISBOA-01-0145-FEDER-016405) and through CrossAtlantic project (PTDC/BIA-OUT/29250/2017), co-financed by COMPETE (POCI-01-0145-FEDER-029250). This work was also funded by the Integrated Programme of SR&TD Smart Valorization of Endogenous Marine Biological Resources Under a Changing Climate (Centro-01-0145-FEDER-000018), co-funded by Centro 2020 Programme, Portugal 2020, European Union, through the European Regional Development Fund.

Keywords

Fucus spiralis Seaweeds Antioxidant Oxidative stress Photoprotective Anti-enzymatic Anti-inflammatory Skin microbiome Dermo-cosmetics

URI

http://hdl.handle.net/10400.8/5113

Citation

Freitas, R., Martins, A., Silva, J., Alves, C., Pinteus, S., Alves, J., Teodoro, F., Ribeiro, H. M., Gonçalves, L., Petrovski, Ž., Branco, L., & Pedrosa, R. (2020). Highlighting the Biological Potential of the Brown Seaweed Fucus spiralis for Skin Applications. Antioxidants (Basel, Switzerland), 9(7), 611. https://doi.org/10.3390/antiox9070611