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Anthocyanins, effects in mitochondria and metabolism

2021Book part Restricted access
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dc.contributor.authorMarques-da-Silva, Dorinda
dc.contributor.authorRodrigues, Joaquim Rui
dc.contributor.authorLagoa, Ricardo
dc.date.accessioned2022-10-24T11:09:10Z
dc.date.available2022-10-24T11:09:10Z
dc.date.issued2021
dc.descriptionO livro "Fisiologia Mitocondrial e Moléculas Vegetais: O potencial terapêutico de compostos naturais na saúde mitocondrial" fornece uma visão abrangente da fisiologia mitocondrial ao longo da vida humana, bem como o efeito de moléculas de origem vegetal na saúde mitocondrial. O editor alinhou uma equipe de especialistas em todo o mundo para cobrir os avanços mais interessantes e de alto impacto da pesquisa nesta área. Este livro está estruturado em duas partes que fornecem um equilíbrio entre o conteúdo básico e o aplicado. Parte I fornece uma visão geral da fisiologia mitocondrial, incluindo sua estrutura, dinâmica, biogênese, membranas, transcrição de DNA e tradução na mitocôndria. A Parte I também abrange outros temas, como apoptose. A Parte II cobre o efeito de moléculas derivadas de vegetais específicas na saúde mitocondrial, incluindo antocianinas, cafeína, canabinóides, ácidos carnósico e rosmarínico, flavonóides cítricos, polifenóis, pterostilbeno, resveratrol e sulforafano, entre outros. Fisiologia Mitocondrial e Moléculas Vegetais: O potencial terapêutico de compostos naturais na saúde mitocondrial é um recurso completo para pesquisadores neste campo empolgante. Sua cobertura abrangente o torna particularmente interessante para pesquisadores de biociência dispostos a entender os fundamentos da fisiologia mitocondrial ao longo da vida humana. Pesquisadores clínicos, médicos, nutricionistas, farmacologistas e cientistas esportivos podem ser atraídos pelas informações detalhadas sobre os efeitos na saúde das moléculas de origem vegetal na organela.pt_PT
dc.description.abstractAlterations in mitochondrial function, cellular redox signaling, and metabolism participate in the etiology and progression of different pathological conditions, such as diabetes, cancer, cardiovascular, and neurodegenerative diseases. Epidemiological, preclinical, and clinical studies indicate that anthocyanins afford therapeutic benefits for these pathologies. It is thus important to revise the effects of anthocyanins on mitochondria and metabolism that hold potential for the development of novel health protective methods. The studies available support the ability of certain anthocyanins to prevent damage to mitochondria and to sustain its function. Evidence is more compelling for cyanidin and delphinidin compounds, but promising data could also be found for malvidin, pelargonidin, and protocatechuic acid. Additionally, berry extracts also demonstrated positive outcomes in different models of neurodegeneration, endothelial dysfunction, myocardial damage, metabolic disorders, longevity, and cancer. At the molecular level, major anthocyanins can modulate the expression and activity of mitochondrial proteins, apoptotic and biogenesis factors, antioxidant defenses, inflammation, and the AMPK pathway. Noteworthy, anthocyanins could balance abnormalities in ROS production, respiration, and mitochondrial fragmentation in cells exposed to toxicants or oxidizing agents.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMarques, D., Rodrigues, R. & Lagoa, R. (2021). Anthocyanins, effects in mitochondria and metabolism, In Marcos, O. (Ed.), Mitochondrial Physiology and Vegetal Molecules (267-300). Elsevier - Academic Press. https://doi.org/10.1016/B978-0-12-821562-3.00028-9pt_PT
dc.identifier.doihttps://doi.org/10.1016/C2019-0-04269-0pt_PT
dc.identifier.isbn978-0-12-821562-3
dc.identifier.urihttp://hdl.handle.net/10400.8/7804
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier - Academic Presspt_PT
dc.relationMultifunctional biomolecular systems for new methods of decontamination, protection and toxicological assessment
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/B9780128215623000289?via%3Dihubpt_PT
dc.subjectAnthocyaninspt_PT
dc.subjectAnthocyanidinspt_PT
dc.subjectCyanidin-3-O-glucosidept_PT
dc.subjectNatural compoundspt_PT
dc.subjectOxidative stresspt_PT
dc.subjectRespiratory complexespt_PT
dc.subjectElectron transport chainpt_PT
dc.subjectMitochondrial dynamicspt_PT
dc.subjectMitochondrial biogenesispt_PT
dc.subjectMetabolitespt_PT
dc.titleAnthocyanins, effects in mitochondria and metabolismpt_PT
dc.typebook part
dspace.entity.typePublication
oaire.awardTitleMultifunctional biomolecular systems for new methods of decontamination, protection and toxicological assessment
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-MIB%2F31864%2F2017/PT
oaire.citation.endPage300pt_PT
oaire.citation.startPage267pt_PT
oaire.citation.titleMitochondrial Physiology and Vegetal Molecules: Therapeutic Potential of Natural Compounds on Mitochondrial Healthpt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream3599-PPCDT
person.familyNameRodrigues
person.familyNameLagoa
person.givenNameJoaquim Rui
person.givenNameRicardo
person.identifier124357
person.identifier.ciencia-id521A-35C1-078D
person.identifier.ciencia-id9018-0B83-E2C6
person.identifier.ciencia-id5C18-A29A-44AB
person.identifier.orcid0000-0002-9756-1124
person.identifier.orcid0000-0003-2375-6612
person.identifier.ridL-4137-2014
person.identifier.scopus-author-id35751117400
person.identifier.scopus-author-id10242931100
person.identifier.scopus-author-id23051352300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typebookPartpt_PT
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relation.isAuthorOfPublication.latestForDiscovery20daf20e-f1d3-455c-a6fd-e10754cca411
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