Logo do repositório
 
Publicação

Quality of life after preoperative home-based exercise training in patients with lung cancer: a secondary analysis

2026-03-24Artigo científico Acesso aberto
Ver registo simples
datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorPimenta, Sara
dc.contributor.authorMachado, Pedro
dc.contributor.authorSilva, Cândida G.
dc.contributor.authorGarcia, Ana Luís
dc.contributor.authorNogueira, Tiago
dc.contributor.authorSilva, Sónia
dc.contributor.authorSantos, Claúdia Lares dos
dc.contributor.authorMartins, Maria Vitória
dc.contributor.authorCanha, André
dc.contributor.authorOliveiros, Bárbara
dc.contributor.authorMartins, Raul A.
dc.contributor.authorCruz, Joana
dc.date.accessioned2026-09-07T13:21:11Z
dc.date.available2026-09-07T13:21:11Z
dc.date.issued2026-03-24
dc.descriptionArticle nr 209
dc.descriptionAcknowledgments: This work was previously presented in abstract format at the European Respiratory Society International Congress 2024 (see: https://publications.ersnet.org/content/erj/64/suppl68/pa594).
dc.description.abstractBackground: A preoperative home-based exercise training (PHET) program appeared to improve health-related quality of life (HRQoL) in patients undergoing lung cancer surgery. However, inter-individual variability in response was observed. This secondary analysis aimed to identify characteristics of responders/non-responders to PHET, determine predictors of response, and examine whether preoperative HRQoL response to PHET is associated with postoperative HRQoL maintenance. Methods: This was a secondary analysis of pooled data from a feasibility study and a randomized controlled trial, including sociodemographic/clinical data, physical performance and HRQoL (EORTC-QLQ-C30). Responders/non-responders were classified based on a change of ≥5 points in Global QoL score (EORTC QLQ-C30) from baseline to pre-surgery time point. Between-group differences and predictors of PHET response (logistic regression) were analysed. Results: 32 patients (63% male, 67.1±7.8 years) were included, from which 56% (n=18) were responders to PHET in Global QoL. Responders had lower baseline scores in Global QoL, Emotional Function and Summary Score compared to non-responders (P<0.05), and 50% of responders had chronic obstructive pulmonary disease (COPD) (P=0.02). No other between-group differences were found (P>0.05). In the regression model including the Summary Score (EORTC-QLQ-C30) and COPD (Nagelkerke R2=0.511), COPD was a significant predictor of response: COPD patients were 13.4 times more likely to be responders (odds ratio =13.4; 95% confidence interval: 1.4; 132.2). 65% of PHET-responders maintained/improved HRQoL 1-month post-surgery. Conclusions: Most patients awaiting lung cancer surgery responded in HRQoL to a PHET, however, a considerable proportion did not. Further research is needed to identify characteristics of non-responders and optimize prehabilitation strategies accordingly.eng
dc.description.sponsorshipFunding: S.P. was supported by an MSc fellowship from the Centre for Innovative Care and Health Technology (ciTechCare), funded by the Portuguese Foundation for Science and Technology (FCT) (UIDB/05704/2020) during the study, and P.M. held a PhD fellowship supported by the FCT (UIDB/05704/2020) during the study. The study was supported by ciTechCare, funded by the FCT (UIDB/05704/2025, DOI: https://doi.org/10.54499/UID/05704/2025).
dc.identifier.citationPimenta S, Machado P, Silva CG, Garcia AL, Nogueira T, Silva S, dos Santos CL, Martins MV, Canha A, Oliveiros B, Martins RA, Cruz J. Quality of life after preoperative home-based exercise training in patients with lung cancer: a secondary analysis. J Thorac Dis 2026;18(3):209. doi: 10.21037/jtd-2025-1444
dc.identifier.doi10.21037/jtd-2025-1444
dc.identifier.eissn2077-6624
dc.identifier.issn2072-1439
dc.identifier.urihttp://hdl.handle.net/10400.8/16789
dc.language.isoeng
dc.peerreviewedyes
dc.publisherAME Publishing Company
dc.relationCenter for Innovative Care and Health Technology
dc.relationCenter for Innovative Care and Health Technology
dc.relation.hasversionhttps://jtd.amegroups.org/article/view/114647/html
dc.relation.ispartofJournal of Thoracic Disease
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectHealth-related quality of life (HRQoL)
dc.subjectLung cancer
dc.subjectPrehabilitation
dc.titleQuality of life after preoperative home-based exercise training in patients with lung cancer: a secondary analysiseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDB/05704/2020
oaire.awardNumberUID/05704/2025
oaire.awardTitleCenter for Innovative Care and Health Technology
oaire.awardTitleCenter for Innovative Care and Health Technology
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05704%2F2020/PT
oaire.awardURIhttp://hdl.handle.net/10400.8/16767
oaire.citation.endPage14
oaire.citation.issue3
oaire.citation.startPage1
oaire.citation.titleJournal of Thoracic Disease
oaire.citation.volume18
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamAvaliação UID 2023/2024
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNamePimenta
person.familyNameMachado
person.familyNameSilva
person.familyNameCruz
person.givenNameSara
person.givenNamePedro
person.givenNameCândida
person.givenNameJoana
person.identifier1763199
person.identifier.ciencia-id1D15-572F-4302
person.identifier.ciencia-id111A-3F47-19CD
person.identifier.ciencia-idD513-D305-7FD1
person.identifier.ciencia-idE213-7D20-5C3C
person.identifier.orcid0000-0003-0036-4106
person.identifier.orcid0000-0003-1147-2778
person.identifier.orcid0000-0002-7092-1169
person.identifier.orcid0000-0002-4911-4469
person.identifier.ridK-7030-2013
person.identifier.scopus-author-id55429869600
person.identifier.scopus-author-id36715922000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication1e1bf245-7bca-47de-b4b3-93af0df09cba
relation.isAuthorOfPublication7e59cca8-9db1-42b3-baa0-aff90405d499
relation.isAuthorOfPublicationfd13edbb-44ba-42ba-a658-8f7ed862b0b1
relation.isAuthorOfPublication33428074-748a-4751-b2f7-9f24247715fd
relation.isAuthorOfPublication.latestForDiscovery1e1bf245-7bca-47de-b4b3-93af0df09cba
relation.isProjectOfPublicationd421b07d-3471-4026-aa43-def80b8e142b
relation.isProjectOfPublication0cff4974-844d-4013-8925-4077ed05335a
relation.isProjectOfPublication.latestForDiscoveryd421b07d-3471-4026-aa43-def80b8e142b

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Quality of life after preoperative home-based exercise training in patients with lung cancer -a secondary analysis.pdf
Tamanho:
388.29 KB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
1.32 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

ciTechCare - Artigos
ESSLei - Artigos em revistas internacionais