Characterization of antiproliferative potential and biological targets of a copper compound containing 4′-phenyl terpyridine

Mendo, Ana Soraia; Figueiredo, Sara; Roma-Rodrigues, Catarina; Videira, Paula A.; Ma, Zhen; Diniz, Mário; Larguinho, Miguel; Costa, Pedro M.; Lima, João C.; Pombeiro, Armando J. L.; Baptista, Pedro V.; Fernandes, Alexandra R.

http://hdl.handle.net/10400.8/13254

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Authors

Mendo, Ana Soraia

Figueiredo, Sara

Roma-Rodrigues, Catarina

Pombeiro, Armando J. L.

Abstract(s)

Several copper complexes have been assessed as anti-tumor agents against cancer cells. In this work, a copper compound [Cu(H2O){OS(CH3)2}L](NO3)2 incorporating the ligand 4′-phenyl-terpyridine antiproliferative activity against human colorectal, hepatocellular carcinomas and breast adenocarcinoma cell lines was determined, demonstrating high cytotoxicity. The compound is able to induce apoptosis and a slight delay in cancer cell cycle progression, probably by its interaction with DNA and induction of double-strand pDNA cleavage, which is enhanced by oxidative mechanisms. Moreover, proteomic studies indicate that the compound induces alterations in proteins involved in cytoskeleton maintenance, cell cycle progression and apoptosis, corroborating its antiproliferative potential.

Keywords

Anticancer drug Apoptosis Biomedicine DNA damage Nucleic acid

URI

http://hdl.handle.net/10400.8/13254

Citation

Mendo, A.S., Figueiredo, S., Roma-Rodrigues, C. et al. Characterization of antiproliferative potential and biological targets of a copper compound containing 4′-phenyl terpyridine. J Biol Inorg Chem 20, 935–948 (2015). https://doi.org/10.1007/s00775-015-1277-z