Silence is golden (siAu) - silencing the silencers via multifunctional gold nanoconjugates towards cancer therapy

Publicações

Characterization of antiproliferative potential and biological targets of a copper compound containing 4′-phenyl terpyridine

Publication . Mendo, Ana Soraia; Figueiredo, Sara; Roma-Rodrigues, Catarina; Videira, Paula A.; Ma, Zhen; Diniz, Mário; Larguinho, Miguel; Costa, Pedro M.; Lima, João C.; Pombeiro, Armando J. L.; Baptista, Pedro V.; Fernandes, Alexandra R.

Several copper complexes have been assessed as anti-tumor agents against cancer cells. In this work, a copper compound [Cu(H2O){OS(CH3)2}L](NO3)2 incorporating the ligand 4′-phenyl-terpyridine antiproliferative activity against human colorectal, hepatocellular carcinomas and breast adenocarcinoma cell lines was determined, demonstrating high cytotoxicity. The compound is able to induce apoptosis and a slight delay in cancer cell cycle progression, probably by its interaction with DNA and induction of double-strand pDNA cleavage, which is enhanced by oxidative mechanisms. Moreover, proteomic studies indicate that the compound induces alterations in proteins involved in cytoskeleton maintenance, cell cycle progression and apoptosis, corroborating its antiproliferative potential.

2015-06Artigo científico

Acesso restrito

Ver mais

Palavras-chave

multifunctional gold nanoparticles,nanomedicine,cancer,therapy, Engineering and technology ,Engineering and technology/Nano-technology

Entidade financiadora

Fundação para a Ciência e a Tecnologia, I.P.
Fundação para a Ciência e a Tecnologia, I.P.

Programa de financiamento

3599-PPCDT
Projetos de Investigação Científica e Desenvolvimento Tecnológico - 2012

Número da atribuição

PTDC/BBB-NAN/1812/2012