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Characterization of antiproliferative potential and biological targets of a copper compound containing 4′-phenyl terpyridine

2015-06Journal article Restricted access
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorMendo, Ana Soraia
dc.contributor.authorFigueiredo, Sara
dc.contributor.authorRoma-Rodrigues, Catarina
dc.contributor.authorVideira, Paula A.
dc.contributor.authorMa, Zhen
dc.contributor.authorDiniz, Mário
dc.contributor.authorLarguinho, Miguel
dc.contributor.authorCosta, Pedro M.
dc.contributor.authorLima, João C.
dc.contributor.authorPombeiro, Armando J. L.
dc.contributor.authorBaptista, Pedro V.
dc.contributor.authorFernandes, Alexandra R.
dc.date.accessioned2025-06-16T11:23:31Z
dc.date.available2025-06-16T11:23:31Z
dc.date.issued2015-06
dc.description.abstractSeveral copper complexes have been assessed as anti-tumor agents against cancer cells. In this work, a copper compound [Cu(H2O){OS(CH3)2}L](NO3)2 incorporating the ligand 4′-phenyl-terpyridine antiproliferative activity against human colorectal, hepatocellular carcinomas and breast adenocarcinoma cell lines was determined, demonstrating high cytotoxicity. The compound is able to induce apoptosis and a slight delay in cancer cell cycle progression, probably by its interaction with DNA and induction of double-strand pDNA cleavage, which is enhanced by oxidative mechanisms. Moreover, proteomic studies indicate that the compound induces alterations in proteins involved in cytoskeleton maintenance, cell cycle progression and apoptosis, corroborating its antiproliferative potential.eng
dc.description.sponsorshipFunding text We thank FCT/MEC for financial support (PTDC/BBB-NAN/1812/2012; PEst-OE/QUI/UI0100/2013). We also thank A. Silva, J. Palma, L. Coito and J. Silva for technical support; and G. Cabral (CEDOC, FCM/UNL) for technical support with flow cytometry assays.
dc.identifier.citationMendo, A.S., Figueiredo, S., Roma-Rodrigues, C. et al. Characterization of antiproliferative potential and biological targets of a copper compound containing 4′-phenyl terpyridine. J Biol Inorg Chem 20, 935–948 (2015). https://doi.org/10.1007/s00775-015-1277-z
dc.identifier.doi10.1007/s00775-015-1277-z
dc.identifier.issn0949-8257
dc.identifier.issn1432-1327
dc.identifier.urihttp://hdl.handle.net/10400.8/13254
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Nature
dc.relationSilence is golden (siAu) - silencing the silencers via multifunctional gold nanoconjugates towards cancer therapy
dc.relationStrategic Project - UI 100 - 2013-2014
dc.relation.hasversionhttps://link.springer.com/article/10.1007/s00775-015-1277-z
dc.relation.ispartofJBIC Journal of Biological Inorganic Chemistry
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAnticancer drug
dc.subjectApoptosis
dc.subjectBiomedicine
dc.subjectDNA damage
dc.subjectNucleic acid
dc.titleCharacterization of antiproliferative potential and biological targets of a copper compound containing 4′-phenyl terpyridineeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSilence is golden (siAu) - silencing the silencers via multifunctional gold nanoconjugates towards cancer therapy
oaire.awardTitleStrategic Project - UI 100 - 2013-2014
oaire.awardURIhttp://hdl.handle.net/10400.8/13252
oaire.awardURIhttp://hdl.handle.net/10400.8/13253
oaire.citation.endPage948
oaire.citation.issue6
oaire.citation.startPage935
oaire.citation.titleJBIC Journal of Biological Inorganic Chemistry
oaire.citation.volume20
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCosta
person.givenNamePedro M.
person.identifier.orcid0000-0002-9072-3522
relation.isAuthorOfPublication01d7c7c5-8ff1-48c8-a0ca-576b1e89a02c
relation.isAuthorOfPublication.latestForDiscovery01d7c7c5-8ff1-48c8-a0ca-576b1e89a02c
relation.isProjectOfPublication58470b3e-1573-4d09-ba58-4692f2e1fee7
relation.isProjectOfPublication8b22e465-ed76-476c-bdd7-cf3f3cd81cd3
relation.isProjectOfPublication.latestForDiscovery58470b3e-1573-4d09-ba58-4692f2e1fee7

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