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Effect of Preoperative Home-Based Exercise Training on Quality of Life After Lung Cancer Surgery: A Multicenter Randomized Controlled Trial

2023Journal article Open access
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dc.contributor.authorMachado, Pedro
dc.contributor.authorPimenta, Sara
dc.contributor.authorGarcia, Ana Luís
dc.contributor.authorNogueira, Tiago
dc.contributor.authorSilva, Sónia
dc.contributor.authorSantos, Cláudia Lares dos
dc.contributor.authorMartins, Maria Vitória
dc.contributor.authorCanha, André
dc.contributor.authorOliveiros, Bárbara
dc.contributor.authorMartins, Raul A.
dc.contributor.authorCruz, Joana
dc.date.accessioned2023-11-13T10:43:15Z
dc.date.available2023-11-13T10:43:15Z
dc.date.issued2023
dc.description.abstractBackground. Preoperative exercise training is recommended for improvement of clinical outcomes after lung cancer (LC) surgery. However, its efectiveness in preventing postoperative decline in quality of life (QoL) remains unknown. This study investigated the efect of preoperative home-based exercise training (PHET) on QoL after LC surgery. Methods. Patients awaiting LC resection were randomized to PHET or a control group (CG). The PHET program combined aerobic and resistance exercise, with weekly telephone supervision. Primary outcome was QoL-assessed with the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire C30 (QLQC30) at baseline, before surgery, and 1 month after surgery. The secondary outcomes were hospital length of stay and physical performance. The main analysis included a factorial repeated-measures analysis of variance. Additionally, the proportion of patients experiencing clinical deterioration from baseline to post-surgery was assessed. Results. The study included 41 patients (68.1±9.3 years; 68.3% male) in the intention-to-treat analysis (20 PHET patients, 21 CG patients). A signifcant group × time interaction was observed for global QoL (p =0.004). Betweengroup diferences in global QoL were statistically and clinically signifcant before surgery (mean diference [MD], 13.5 points; 95% confdence interval [CI], 2.4–24.6; p =0.019) and after surgery (MD, 12.4 points; 95% CI, 1.3–23.4; p=0.029), favoring PHET. Clinical deterioration of global QoL was reported by 71.4% of the CG patients compared with 30 % of the PHET patients (p =0.003). Between-group diferences in favor of PHET were found in pain and appetite loss as well as in physical, emotional and role functions after surgery (p <0.05). Compared with CG, PHET was superior in improving preoperative fve-times sit-to-stand and postoperative exercise capacity (p <0.05). No between-group diferences in other secondary outcomes were observed. Conclusion. The study showed that PHET can efectively prevent the decline in QoL after LC surgery.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMachado, P., Pimenta, S., Garcia, A.L. et al. Effect of Preoperative Home-Based Exercise Training on Quality of Life After Lung Cancer Surgery: A Multicenter Randomized Controlled Trial. Ann Surg Oncol (2023). https://doi.org/10.1245/s10434-023-14503-2pt_PT
dc.identifier.doihttps://doi.org/10.1245/s10434-023-14503-2pt_PT
dc.identifier.eissn1534-4681
dc.identifier.issn1068-9265
dc.identifier.urihttp://hdl.handle.net/10400.8/8909
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationCenter for Innovative Care and Health Technology
dc.relation.publisherversionhttps://link.springer.com/article/10.1245/s10434-023-14503-2pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectLung cancerpt_PT
dc.subjectSurgical resectionpt_PT
dc.subjectPrehabilitationpt_PT
dc.subjectHome-based exercise trainingpt_PT
dc.subjectQuality of lifept_PT
dc.titleEffect of Preoperative Home-Based Exercise Training on Quality of Life After Lung Cancer Surgery: A Multicenter Randomized Controlled Trialpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCenter for Innovative Care and Health Technology
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05704%2F2020/PT
oaire.citation.titleAnnals of Surgical Oncologypt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMachado
person.familyNamePimenta
person.familyNameSilva
person.familyNameOliveiros
person.familyNameMartins
person.familyNameCruz
person.givenNamePedro
person.givenNameSara
person.givenNameSónia
person.givenNameBárbara
person.givenNameRaul A.
person.givenNameJoana
person.identifier1763199
person.identifierAAR-4529-2020
person.identifier.ciencia-id111A-3F47-19CD
person.identifier.ciencia-id1D15-572F-4302
person.identifier.ciencia-id801F-1C6A-8BD1
person.identifier.ciencia-idC311-469D-6BBC
person.identifier.ciencia-idE213-7D20-5C3C
person.identifier.orcid0000-0003-1147-2778
person.identifier.orcid0000-0003-0036-4106
person.identifier.orcid0000-0002-3655-5580
person.identifier.orcid0000-0001-7836-8161
person.identifier.orcid0000-0003-1194-4560
person.identifier.orcid0000-0002-4911-4469
person.identifier.ridK-7030-2013
person.identifier.scopus-author-id7801350857
person.identifier.scopus-author-id55664310300
person.identifier.scopus-author-id36715922000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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