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- Effectiveness of exercise training on cancer-related fatigue in colorectal cancer survivors: a systematic review and meta-analysis of randomized controlled trialsPublication . Machado, Pedro; Morgado, Miguel; Raposo, João; Mendes, Marco; Silva, Cândida G.; Morais, NunoPurpose: To investigate the effects of exercise training on cancer-related fatigue (CRF) in colorectal cancer survivors. Methods: Randomized controlled trials published between 1 January 2010 and 19 October 2020, selected through online search conducted in PubMed, Scopus, Web of Science, SPORTDiscus and PEDro databases, were included. Eligible trials compared the effect of exercise training interventions, versus non-exercise controls on CRF, in colorectal cancer survivors, during or after treatment. The methodological quality of individual studies was analysed using the Physiotherapy Evidence Database (PEDro) scale. Standardized mean differences (SMD) that were pooled using random-effects models were included as the effect size. In addition, 95% prediction intervals (PI) were calculated. Results: Six trials involving 330 colorectal cancer patients met the inclusion criteria and presented reasonable to good methodological quality. An overall small-to-moderate effect of exercise training on CRF was found (SMD = - 0.29: 95% CI: [- 0.53; - 0.06]; p = 0.01; PI: [- 0.63; 0.04]; low-quality evidence). Subgroup analysis revealed moderate effects of exercise interventions performed during chemotherapy (SMD = - 0.63; 95% CI: [- 1.06; - 0.21]; p = 0.003) and small, non-significant effects, when exercise training was performed after cancer treatment (SMD = - 0.14; 95% CI: [- 0.43; 0.14]; p = 0.32). Steady improvements were achieved when a combination of aerobic plus resistance exercise was used, in interventions lasting 12 to 24 weeks. Conclusion: Exercise training could be regarded as a supportive therapy for the clinical management of CRF in colorectal cancer patients undergoing chemotherapy, but further studies are necessary to clarify the effects of exercise interventions on CRF after cancer treatment.
- OncoEnergy - Manual de exercício físico para pessoas com cancroPublication . Machado, Pedro; Morgado, Miguel; Raposo, João; Mendes, Marco; Ferreira, Luís Eva; Roque, AnaO presente manual foi desenvolvido por estudantes da Licenciatura em Fisioterapia (Unidade Curricular de Educação e Comunicação em Saúde) e investigadores do Centro de Inovação em Tecnologias e Cuidados de Saúde (ciTechCare) da Escola Superior de Saúde do Instituto Politécnico de Leiria, baseando-se num documento semelhante criado pela Associação Australiana de Ciências do Desporto. A informação apresentada baseia-se igualmente nas orientações de instituições internacionais de referência nas áreas da oncologia e do exercício, nomeadamente a European Society of Medical Oncology, American Society of Oncology, Cancer Council e o American College of Sports Medicine.