ESTG - Artigos em revistas internacionais
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Browsing ESTG - Artigos em revistas internacionais by Sustainable Development Goals (SDG) "03:Saúde de Qualidade"
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- 3D Photo-Fabrication for Tissue Engineering and Drug DeliveryPublication . Brás Pereira, Rúben Filipe; Bartolo, PauloThe most promising strategies in tissue engineering involve the integration of a triad of biomaterials, living cells, and biologically active molecules to engineer synthetic environments that closely mimic the healing milieu present in human tissues, and that stimulate tissue repair and regeneration. To be clinically effective, these environments must replicate, as closely as possible, the main characteristics of the native extracellular matrix (ECM) on a cellular and subcellular scale. Photo-fabrication techniques have already been used to generate 3D environments with precise architectures and heterogeneous composition, through a multi-layer procedure involving the selective photocrosslinking reaction of a light-sensitive prepolymer. Cells and therapeutic molecules can be included in the initial hydrogel precursor solution, and processed into 3D constructs. Recently, photo-fabrication has also been explored to dynamically modulate hydrogel features in real time, providing enhanced control of cell fate and delivery of bioactive compounds. This paper focuses on the use of 3D photo-fabrication techniques to produce advanced constructs for tissue regeneration and drug delivery applications. State-of-the-art photo-fabrication techniques are described, with emphasis on the operating principles and biofabrication strategies to create spatially controlled patterns of cells and bioactive factors. Considering its fast processing, spatiotemporal control, high resolution, and accuracy, photo-fabrication is assuming a critical role in the design of sophisticated 3D constructs. This technology is capable of providing appropriate environments for tissue regeneration, and regulating the spatiotemporal delivery of therapeutics.
- 3D printing of new biobased unsaturated polyesters by microstereo-thermal-lithographyPublication . Gonçalves, Filipa A. M. M.; Costa, Cátia S. M. F.; Fabela, Inês G. P.; Farinha, Dina; Faneca, Henrique; Simões, Pedro N.; Serra, Arménio C.; Bártolo, Paulo J.; Coelho, Jorge F. J.New micro three-dimensional (3D) scaffolds using biobased unsaturated polyesters (UPs) were prepared by microstereo-thermal-lithography (μSTLG). This advanced processing technique offers indubitable advantages over traditional printing methods. The accuracy and roughness of the 3D structures were evaluated by scanning electron microscopy and infinite focus microscopy, revealing a suitable roughness for cell attachment. UPs were synthesized by bulk polycondensation between biobased aliphatic diacids (succinic, adipic and sebacic acid) and two different glycols (propylene glycol and diethylene glycol) using fumaric acid as the source of double bonds. The chemical structures of the new oligomers were confirmed by proton nuclear magnetic resonance spectra, attenuated total reflectance Fourier transform infrared spectroscopy and matrix assisted laser desorption/ionization-time of flight mass spectrometry. The thermal and mechanical properties of the UPs were evaluated to determine the influence of the diacid/glycol ratio and the type of diacid in the polyester's properties. In addition an extensive thermal characterization of the polyesters is reported. The data presented in this work opens the possibility for the use of biobased polyesters in additive manufacturing technologies as a route to prepare biodegradable tailor made scaffolds that have potential applications in a tissue engineering area.
- Application of curcuminoids in inflammatory, neurodegenerative and aging conditions - Pharmacological potential and bioengineering approaches to improve efficiencyPublication . Lagoa, Ricardo; Rajan, Logesh; Violante, Cristiana; Babiaka, Smith B.; Marques da Silva, Dorinda; Kapoor, Bhupinder; Reis, Flávio; Atanasov, Atanas G.Curcumin, a natural compound found in turmeric, has shown promise in treating brain-related diseases and conditions associated with aging. Curcumin has shown multiple anti-inflammatory and brain-protective effects, but its clinical use is limited by challenges like poor absorption, specificity and delivery to the right tissues. A range of contemporary approaches at the intersection with bioengineering and systems biology are being explored to address these challenges. Data from preclinical and human studies highlight various neuroprotective actions of curcumin, including the inhibition of neuroinflammation, modulation of critical cellular signaling pathways, promotion of neurogenesis, and regulation of dopamine levels. However, curcumin’s multifaceted effects - such as its impact on microRNAs and senescence markers - suggest novel therapeutic targets in neurodegeneration. Tetrahydrocurcumin, a primary metabolite of curcumin, also shows potential due to its presence in circulation and its anti-inflammatory properties, although further research is needed to elucidate its neuroprotective mechanisms. Recent advancements in delivery systems, particularly brain-targeting nanocarriers like polymersomes, micelles, and liposomes, have shown promise in enhancing curcumin’s bioavailability and therapeutic efficacy in animal models. Furthermore, the exploration of drug-laden scaffolds and dermal delivery may extend the pharmacological applications of curcumin. Studies reviewed here indicate that engineered dermal formulations and devices could serve as viable alternatives for neuroprotective treatments and to manage skin or musculoskeletal inflammation. This work highlights the need for carefully designed, long-term studies to better understand how curcumin and its bioactive metabolites work, their safety, and their effectiveness.
- Biomanufacturing for tissue engineering: Present and future trendsPublication . Bartolo, Paulo; Chua, C. K.; Almeida, Henrique de Amorim; Chou, S. M.; Lim, A. S. C.Tissue engineering, often referred to as regenerative medicine and reparative medicine, is an interdisciplinary field that necessitates the combined effort of cell biologists, engineers, material scientists, mathematicians, geneticists, and clinicians toward the development of biological substitutes that restore, maintain, or improve tissue function. It has emerged as a rapidly expanding approach to address the organ shortage problem and comprises tissue regeneration and organ substitution. Cells placed on/or within constructs is the most common strategy in tissue engineering. Successful cell seeding depends on fast attachment of cell to scaffolds, high cell survival and uniform cell distribution. The seeding time is strongly dependent on the scaffold material and architecture. Scaffolds provide an initial biochemical substrate for the novel tissue until cells can produce their own extra-cellular matrix (ECM). Thus scaffolds not only define the 3D space for the formation of new tissues, but also serve to provide tissues with appropriate functions. These scaffolds are often critical, both in vivo (within the body) or in vitro (outside the body) mimicking in vivo conditions. Additive fabrication processes represent a new group of non-conventional fabrication techniques recently introduced in the biomedical engineering field. In tissue engineering, additive fabrication processes have been used to produce scaffolds with customised external shape and predefined internal morphology, allowing good control of pore size and pore distribution. This article provides a comprehensive state-of-the-art review of the application of biomanufacturing additive processes in the field of tissue engineering. New and moving trends in biomanufacturing technologies and the concept of direct cell-printing technologies are also discussed.
- Classification of reticular pattern and streaks in dermoscopic images based on texture analysisPublication . Machado, Marlene; Pereira, Jorge; Fonseca-Pinto, RuiThe early detection of melanoma is one of the greatest challenges in clinical practice of dermatology, and the reticular pattern is one of the most important dermoscopic structures to improve melanocytic lesion diagnosis. A texture-based approach is developed for the automatic detection of reticular patterns, whose output will assist clinical decision-making. Feature selection was based on the use of two algorithms by means of the classical graylevel co-occurrence matrix and Laws energy masks optimized on a set of 104 dermoscopy images. The AdaBoost (adaptive boosting) approach to machine learning was used within this strategy. Results suggest superiority of LEM for reticular pattern detection in dermoscopic images, achieving a sensitivity of 90.16% and a specificity of 86.67%. The use of automatic classification in dermoscopy to support clinicians is a strong tool to assist diagnosis; however, the use of automatic classification as a complementary tool in clinical routine requires algorithms with high levels of sensitivity and specificity. The results presented in this work will contribute to achieving this goal.
- Comparative Analysis of Pressure Platform and Insole Devices for Plantar Pressure AssessmentPublication . Amaro, Catarina M.; Paulino, Maria F.; Valvez, Sara; Roseiro, Luis; Castro, Maria António; Amaro, Ana M.Foot plantar pressure refers to the pressure or force that the foot generates in contact with the ground, varying across different regions of the foot. This parameter is essential in static and dynamic analyses to access accurate diagnoses, study the human body biomechanics, create functional footwear designs, aid in rehabilitation and physiotherapy, and prevent injuries in athletes during sports practice. This study presents an experimental comparison between two different plantar pressure measurement devices, Pedar® (sensorized insoles) and Physiosensing® (pressure platform). The devices were selected based on their capacity to measure contact area and peak pressure points. Results showed that Physiosensing® provided a more uniform measurement of the contact area, proving its efficiency for weight distribution and stability analysis applications, particularly in posture assessment and balance studies. The Pedar® system showed higher capacity in peak pressure point detection. Therefore, the insole system is more suitable for applications requiring precise high-pressure zone localization. Comparative analysis highlights the strengths and limitations of each device and offers insights regarding its optimal usage in clinical, sports, and research settings.
- Design of a Video Otoscope Prototype with an Integrated Scanner for Hearing Aid Direct Digital Manufacturing: A Preliminary StudyPublication . Ganhão, Francisco; Santos, António Carvalho; Silva, Carla; Monteiro de Moura, Carla SofiaIn the current landscape of hearing rehabilitation, ear mold manufacturing typically involves the injection of silicone into the external ear canal (EEC) of each patient. This invasive procedure poses several risks, including the potential for silicone residue retention and tympanic membrane perforation, which may necessitate surgical intervention. To mitigate these risks, we present the design of a video otoscope that integrates a scanner capable of capturing high-precision, real-time images of the EEC’s geometry. The developed device allows (i) the generation of a 3D CAD model leading to the direct, quick, and low-cost production of customized hearing aids using 3D printing and (ii) the establishment of medical protocols for carrying out diagnoses and monitoring of hearing pathology evolution using methodologies based on Artificial Intelligence. Furthermore, the use of customized hearing aids that allow the application of Rhythmic Auditory Stimulation (RAS) and music therapy enhances audiology as an alternative and innovative way to treat cognitive and degenerative diseases, as well as pathological disorders.
- Effect of asymmetrical rolling and annealing the mechanical response of an 1050-o sheetPublication . Simões, Fábio; Sousa, Ricardo J. Alves de; Grácio, José J. A.; Barlat, Frédéric; Yoon, Jeong WhanThe asymmetrical rolling process has been studied as a way to promote intense shear deformations across the sheet thickness. These shear deformations may lead, given the proper conditions, to the development of shear texture components ({001}<110>, {111}<110> and {111}<112>) and also grain refinement. In this work, a 1050-O sheet is asymmetrically rolled and annealed. Conventional rolling is also performed, for comparison purposes. Shear texture components are obtained for the asymmetrically rolled specimens, and seem to be retained after annealing. Differences in mechanical response between asymmetrical and conventionally rolled specimens, as well as texture evolution after heat treatment processing are inferred based on experimental tensile and shear tests. Numerical simulations are used to help explain the differences found on experimental tests. It is proven that it is difficult to spread shear texture through the entire sheet thickness from a general asymmetric rolling process. Based on the fact, future research is discussed at closure.
- Fast video encoding based on random forestsPublication . Tahir, Muhammad; Taj, Imtiaz A.; Assuncao, Pedro A. A.; Asif, MuhammadMachine learning approaches have been increasingly used to reduce the high computational complexity of high-efficiency video coding (HEVC), as this is a major limiting factor for real-time implementations, due to the decision process required to find optimal coding modes and partition sizes for the quad-tree data structures defined by the standard. This paper proposes a systematic approach to reduce the computational complexity of HEVC based on an ensemble of online and offline Random Forests classifiers. A reduced set of features for training the Random Forests classifier is proposed, based on the rankings obtained from information gain and a wrapper-based approach. The best model parameters are also obtained through a consistent and generalizable method. The proposed Random Forests classifier is used to model the coding unit and transform unit-splitting decision and the SKIP-mode prediction, as binary classification problems, taking advantage from the combination of online and offline approaches, which adapts better to the dynamic characteristics of video content. Experimental results show that, on average, the proposed approach reduces the computational complexity of HEVC by 62.64% for the random access (RA) profile and 54.57% for the low-delay (LD) main profile, with an increase in BD-Rate of 2.58% for RA and 2.97% for LD, respectively. These results outperform the previous works also using ensemble classifiers for the same purpose.
- Fatigue Crack Growth in Maraging Steel Obtained by Selective Laser MeltingPublication . Capela, Carlos; Lima Santos, Luís; Antunes, Fernando; Ferreira, José; Costa, José; Jesus, Joel; Prates, PedroThe fatigue crack growth properties of G20Mn5QT cast steel and corresponding butt welds, using compact tension specimens, were monitored and investigated via acoustic emission (AE) techniques. Fatigue crack growth is a combination of cyclic plastic deformations before the crack tip, tensile crack fractures, and shear crack fractures. The cyclic plastic deformations release the maximum amount of energy, which accounts for half of the total energy, and the second-largest number of AE signals, which are of the continuous-wave type. The tensile crack fractures release the second-largest amount of energy and the largest number of AE signals, which are of the burst-wave type. The shear crack fractures release the least amount of energy and the lowest number of AE signals, which are similar to the burst type, albeit with a relatively longer rise time and duration. Crack tip advancement can be regarded as a discontinuous process. The critical area before the crack tip brittlely ruptures when the fatigue damage caused by cyclic plastic deformations reaches critical status. The ruptures produce a large number of tensile crack fractures and rare shear crack fractures. Through fractography observation, the shear crack fractures occur probabilistically around defects caused by casting or welding, which lead to stress and strain in the local complex.
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