Browsing by Issue Date, starting with "2025-09"
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- Decrypting messages: Extracting digital evidence from signal desktop for windowsPublication . Paulino, Gonçalo; Negrão, Miguel; Frade, Miguel; Domingues, PatrícioWith growing concerns over the security and privacy of personal conversations, end-to-end encrypted instant messaging applications have become a key focus of forensic research. This study presents a detailed methodology along with an automated Python script for decrypting and analyzing forensic artifacts from Signal Desktop for Windows. The methodology is divided into two phases: i) decryption of locally stored data and ii) analysis and documentation of forensic artifacts. To ensure data integrity, the proposed approach enables retrieval without launching Signal Desktop, preventing potential alterations. Additionally, a reporting module organizes extracted data for forensic investigators, enhancing usability. Our approach is effective in extracting and analyzing encrypted Signal artifacts, providing a reliable method for forensic investigations.
- Application of curcuminoids in inflammatory, neurodegenerative and aging conditions - Pharmacological potential and bioengineering approaches to improve efficiencyPublication . Lagoa, Ricardo; Rajan, Logesh; Violante, Cristiana; Babiaka, Smith B.; Marques da Silva, Dorinda; Kapoor, Bhupinder; Reis, Flávio; Atanasov, Atanas G.Curcumin, a natural compound found in turmeric, has shown promise in treating brain-related diseases and conditions associated with aging. Curcumin has shown multiple anti-inflammatory and brain-protective effects, but its clinical use is limited by challenges like poor absorption, specificity and delivery to the right tissues. A range of contemporary approaches at the intersection with bioengineering and systems biology are being explored to address these challenges. Data from preclinical and human studies highlight various neuroprotective actions of curcumin, including the inhibition of neuroinflammation, modulation of critical cellular signaling pathways, promotion of neurogenesis, and regulation of dopamine levels. However, curcumin’s multifaceted effects - such as its impact on microRNAs and senescence markers - suggest novel therapeutic targets in neurodegeneration. Tetrahydrocurcumin, a primary metabolite of curcumin, also shows potential due to its presence in circulation and its anti-inflammatory properties, although further research is needed to elucidate its neuroprotective mechanisms. Recent advancements in delivery systems, particularly brain-targeting nanocarriers like polymersomes, micelles, and liposomes, have shown promise in enhancing curcumin’s bioavailability and therapeutic efficacy in animal models. Furthermore, the exploration of drug-laden scaffolds and dermal delivery may extend the pharmacological applications of curcumin. Studies reviewed here indicate that engineered dermal formulations and devices could serve as viable alternatives for neuroprotective treatments and to manage skin or musculoskeletal inflammation. This work highlights the need for carefully designed, long-term studies to better understand how curcumin and its bioactive metabolites work, their safety, and their effectiveness.