Advances in phytochemical delivery systems for improved anticancer activity

Lagoa, Ricardo; Silva, João; Rodrigues, Joaquim Rui; Bishayee, Anupam

http://hdl.handle.net/10400.8/14357

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Advances in phytochemical delivery systems for improved anticancer activity.pdf	Natural compounds have significant anticancer pharmacological activities, but often suffer from low bioavailability and selectivity that limit therapeutic use. The present work critically analyzes the latest advances on drug delivery systems designed to enhance pharmacokinetics, targeting, cellular uptake and efficacy of anticancer phytoconstituents. Various phytochemicals, including flavonoids, resveratrol, celastrol, curcumin, berberine and camptothecins, carried by liposomes, nanoparticles, nanoemulsions and films showed promising results. Strategies to avoid drug metabolism, overcome physiological barriers and achieve higher concentration at cancer sites through skin, buccal, nasal, vaginal, pulmonary and colon targeted delivery are presented. Current limitations, challenges and future research directions are also discussed.	1.53 MB	Adobe PDF	Download

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Authors

Lagoa, Ricardo

Silva, João

Rodrigues, Joaquim Rui

Bishayee, Anupam

Abstract(s)

Natural compounds have significant anticancer pharmacological activities, but often suffer from low bioavailability and selectivity that limit therapeutic use. The present work critically analyzes the latest advances on drug delivery systems designed to enhance pharmacokinetics, targeting, cellular uptake and efficacy of anticancer phytoconstituents. Various phytochemicals, including flavonoids, resveratrol, celastrol, curcumin, berberine and camptothecins, carried by liposomes, nanoparticles, nanoemulsions and films showed promising results. Strategies to avoid drug metabolism, overcome physiological barriers and achieve higher concentration at cancer sites through skin, buccal, nasal, vaginal, pulmonary and colon targeted delivery are presented. Current limitations, challenges and future research directions are also discussed.

Keywords

Cancer Chemoprevention Therapy Nanoparticles Liposomes Drug release Phytochemicals Curcumin Epigallocatechin-3-gallate Clinical trials

URI

http://hdl.handle.net/10400.8/14357

Citation

Ricardo Lagoa, João Silva, Joaquim Rui Rodrigues, Anupam Bishayee, Advances in phytochemical delivery systems for improved anticancer activity, Biotechnology Advances, Volume 38, 2020, 107382, ISSN 0734-9750, https://doi.org/10.1016/j.biotechadv.2019.04.004.