CDRsp - Comunicações em conferências internacionais
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Percorrer CDRsp - Comunicações em conferências internacionais por Domínios Científicos e Tecnológicos (FOS) "Engenharia e Tecnologia::Biotecnologia Industrial"
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- Evaluating the Properties of an Alginate Wound Dressing for Skin RepairPublication . Pereira, Rúben F.; Mendes, Ausenda; Bártolo, Paulo J.The treatment of skin lesions is a costly and complex process, for which different strategies are currently available. In this study, we investigated the properties of novel films composed of alginate and aloe vera gel for application as wound dressing material. The films combine the occlusive and haemostatic properties of calcium alginate gels with the therapeutic properties of aloe vera. We expect that these films may improve the healing process through the release of aloe vera compounds directly into the wound bed and could be an alternative to the administration of synthetic drugs to infected wounds. The films exhibited high transparency in both dry and wet state, as well as adequate mechanical properties for skin use. The results indicated that the films present great potential to be explored as wound dressing material.
- Influence of the Rheological Behaviour in Electrospun PCL Nanofibres Production for Tissue Engineering ApplicationsPublication . Dias, Juliana R.; Antunes, Filipe E.; Bártolo, Paulo J.A strategy to obtain functional tissues engineering with desired biomechanical properties was used to develop scaffolds with morphologies mimicking the native environment to guide tissue regeneration. Nonwoven scaffolds, with fibre dimensions at a nanometre scale, can mimic the physical structure of natural extracellular matrices (ECM). Though its clinical application is yet limited, nano/micro fibrous scaffolds produced by electrospinning gains more and more interest in different Tissue Engineering fields. The electrospinning technique is controlled by several parameters, such as polymer solution and processing ambient, being one of the most important parameters the solution viscosity, which allows defining the minimum viscosity needed to obtain fibres. This research work investigates the rheological behaviour of PCL solutions to produce nanoscale fibre meshes for cartilage application. Poly (ε-caprolactone) (PCL) solutions were prepared using glacial acetic acid (AA) and glacial acetic acid with triethylamine (AA/TEA) at different concentrations. It was necessary to double the value of the critical concentration (c*), that is 10 wt% for PCL/AA and 9,6wt% for PCL/AA/TEA, to prepare suitable fibres. Results also show that a more homogenous mesh can be produced by adding TEA.
- PCL and PCL/PLA Scaffolds for Bone Tissue RegenerationPublication . Patrício, Tatiana; Gloria, Antonio; Bártolo, Paulo J.This paper investigates the use of PCL and PCL/PLA scaffolds, produced using a novel additive biomanufacturing system called BioCell Printing, for bone tissue engineering applications. Results show that the BioCell Printing system produces scaffolds with regular and reproducible architecture, presenting no toxicity and enhancing cell attachment and proliferation. It was also possible to observe that the addition of PLA to PCL scaffolds strongly improves the biomechanical performance of the constructs.
- PCL Scaffolds with Collagen Bioactivator for Applications in Tissue EngineeringPublication . Sousa, Inês; Mendes, Ausenda; Bártolo, Paulo J.The need for human tissues is fundament in certain genetic diseases or accidents of everyday life, they are a primary source for public health. In recent years, to alleviate these effects there was an improvement in the development of tissue engineering, scaffolds or matrices, to support an adequate mechanical and biological environment necessary for the regeneration of damaged tissues. These scaffolds are structures allowing adhesion, differentiation, cell proliferation and the supply of nutrients for growing cells. This paper aims to obtain PCL scaffolds bioactivators, to use as support matrices for the development of human tissues, as PCL is a biomaterial widely used in the biomedical field, due to its biocompatibility, mechanical strength and biodegradability. However, this biomaterial is hydrophobic, which means that there are difficulties in cell adhesion. To solve this problem, a coating of PCL scaffolds with collagen was used, since collagen is a hydrophilic protein existing in the formation of various tissues, so improves cell adhesion.