CDRsp - Comunicações em conferências internacionais
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- Polymers, Biomanufacturing and Regenerative MedicinePublication . Mitchell, Geoffrey R.; Domingos, M.; Bártolo, Paulo J.Polymers have a major contribution to make in the field of regenerative medicine in order to develop and deploy biological substitutes that restore, maintain, or improve tissue function. There are realistic opportunities to create tissues using an engineered extracellular matrix or scaffold and biologically active molecules. A number of different approaches to preparing scaffolds have been explored and the requirements for materials and personalization identified. We review the methodologies and materials available and report on recent work at the CDRSP to integrate and provide control of the processes to provide a realistic biomanufacturing process.
- Tremor modulations across periods with and without voluntary motion and limb load task demands using movement quantificationPublication . Faria , Paula; Patricio, Miguel; Philipiak, Gregor; Caramelo, Francisco; Januario, Cristina; Freire, Antonio; Castelo-Branco, MiguelUnderstanding the neurobiological mechanisms underlying different types of tremor and the altered functional connectivity of the involved areas is a timely goal in clinical neuroscience. If successful, this quest may open new perspectives on how to achieve tremor modulation, which is notably relevant, in Parkinson's disease (PD). Tremor can be characterized by simple parameters such as frequency and amplitude. It is therefore prone to be objectively targeted by neuromodulation and quantitatively investigated using multimodal techniques, such as, accelerometry, EMG and functional Magnetic Resonance Imaging (fMRI). Embarking on the latter challenge requires an a priori knowledge of how effective functional connectivity is altered in PD tremor. This works aims to ascertain which postural and voluntary movement tasks with distinct types of physical load are suitable for designing efficient fMRI protocols, by performing an accelerometry analysis to measure spontaneous and imposed tremor modulation on cohorts of PD patients, essential tremor patients and a group of voluntary healthy controls.