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The Quest for Phenolic Compounds from Macroalgae: A Review of Extraction and Identification Methodologies

2019-12-09Journal article Open access
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datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorSantos, Sónia A. O.
dc.contributor.authorPais, Adriana C. S.
dc.contributor.authorRocha, Sílvia M.
dc.contributor.authorSilvestre, Armando J. D.
dc.contributor.authorFélix, Rafael
dc.date.accessioned2025-10-28T13:01:26Z
dc.date.available2025-10-28T13:01:26Z
dc.date.issued2019-12-09
dc.description.abstractThe current interest of the scientific community for the exploitation of high-value compounds from macroalgae is related to the increasing knowledge of their biological activities and health benefits. Macroalgae phenolic compounds, particularly phlorotannins, have gained particular attention due to their specific bioactivities, including antioxidant, antiproliferative, or antidiabetic. Notwithstanding, the characterization of macroalgae phenolic compounds is a multi-step task, with high challenges associated with their isolation and characterization, due to the highly complex and polysaccharide-rich matrix of macroalgae. Therefore, this fraction is far from being fully explored. In fact, a critical revision of the extraction and characterization methodologies already used in the analysis of phenolic compounds from macroalgae is lacking in the literature, and it is of uttermost importance to compile validated methodologies and discourage misleading practices. The aim of this review is to discuss the state-of-the-art of phenolic compounds already identified in green, red, and brown macroalgae, reviewing their structural classification, as well as critically discussing extraction methodologies, chromatographic separation techniques, and the analytical strategies for their characterization, including information about structural identification techniques and key spectroscopic profiles. For the first time, mass spectrometry data of phlorotannins, a chemical family quite exclusive of macroalgae, is compiled and discussedpor
dc.description.sponsorshipAgroForWealth: Biorefining of agricultural and forest by-products and wastes: integrated strategic for valorisation of resources towards society wealth and sustainability project (CENTRO-01-0145-FEDER-000001), funded by Centro2020, through FEDER and PT2020 for the contract.
dc.identifier.citationSantos, S. A. O., Félix, R., Pais, A. C. S., Rocha, S. M., & Silvestre, A. J. D. (2019). The Quest for Phenolic Compounds from Macroalgae: A Review of Extraction and Identification Methodologies. Biomolecules, 9(12), 847. https://doi.org/10.3390/biom9120847
dc.identifier.doi10.3390/biom9120847
dc.identifier.issn2218-273X
dc.identifier.urihttp://hdl.handle.net/10400.8/14411
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationOrganic Chemistry, Natural Products and Food Stuffs
dc.relationCICECO-Aveiro Institute of Materials
dc.relation.hasversionhttps://www.mdpi.com/2218-273X/9/12/847
dc.relation.ispartofBiomolecules
dc.relation.ispartofseries847
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBioactive compounds
dc.subjectExtraction
dc.subjectCharacterization
dc.subjectMacroalgae
dc.subjectPhenolic Compounds
dc.subjectPhlorotannins
dc.subjectMass spectrometry
dc.subjectSeaweed
dc.titleThe Quest for Phenolic Compounds from Macroalgae: A Review of Extraction and Identification Methodologieseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleOrganic Chemistry, Natural Products and Food Stuffs
oaire.awardTitleCICECO-Aveiro Institute of Materials
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F00062%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FCTM%2F50011%2F2019/PT
oaire.citation.issue12
oaire.citation.titleBiomolecules
oaire.citation.volume9
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFaria da Costa Félix
person.givenNameRafael Alexandre
person.identifierKWTr8tQAAAAJ
person.identifier.ciencia-idA315-5CB0-097C
person.identifier.orcid0000-0003-4766-3736
person.identifier.scopus-author-id57200377641
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublicationd4d70589-8897-4538-b004-bfe2ce623b69
relation.isAuthorOfPublication.latestForDiscoveryd4d70589-8897-4538-b004-bfe2ce623b69
relation.isProjectOfPublication15482869-d4d3-4450-bd6a-34019c121b5b
relation.isProjectOfPublication53206350-2efe-4f4d-ba07-03578d007c85
relation.isProjectOfPublication.latestForDiscovery15482869-d4d3-4450-bd6a-34019c121b5b

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