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Deep Eutectic Systems: A Game Changer for Marine Bioactives Recovery

2025-05-16Journal article Open access
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datacite.subject.sdg12:Produção e Consumo Sustentáveis
datacite.subject.sdg13:Ação Climática
datacite.subject.sdg14:Proteger a Vida Marinha
dc.contributor.authorAmador, Sandro
dc.contributor.authorMartins, Alice
dc.contributor.authorMatias, Margarida
dc.contributor.authorPedrosa, Rui
dc.contributor.authorPinteus, Susete
dc.date.accessioned2025-07-07T09:21:15Z
dc.date.available2025-07-07T09:21:15Z
dc.date.issued2025-05-16
dc.description.abstractThe extraction of bioactive compounds from marine natural products has gained increasing attention due to their diverse applications, such as in pharmaceuticals, nutraceuticals, and cosmetics. Yet, low extraction yields and toxicity associated with common solvents are a major bottleneck. Deep eutectic solvents (DESs) and natural deep eutectic solvents (NADESs) have emerged as promising green alternatives to conventional organic solvents, offering advantages such as biodegradability, greater environmental and economic sustainability, low toxicity, and enhanced extraction selectivity. This review provides a comprehensive analysis of the principles, physicochemical properties, and applications of DESs/NADESs to obtain bioactive compounds from marine organisms. Among the most recent works, it is possible to verify the success of NADESs to extract carrageenan from the seaweed Kappaphycus alvarezii; pigments from Palmaria palmata; and polyphenols and proteins from different brown seaweeds. NADESs have also shown high potential to extract other valuable compounds from marine by-products, such as chitin from crabs and shrimp shells, and also lipids and proteins from different fish species and protein rich extracts from tilapia viscera. The challenges for DESs/NADESs use at industrial scale are also discussed, and success cases are revealed, highlighting their potential as game changers for extracting bioactive compounds from marine organisms and driving the development of innovative biotechnological products.eng
dc.description.sponsorshipThis work was supported by the Portuguese Foundation for Science and Technology (FCT) through the Strategic Projects granted to the MARE—Marine and Environmental Sciences Centre—(DOI 10.54499/UIDP/04292/2020 and DOI 10.54499/UIDB/04292/2020), to the Associate Laboratory ARNET (DOI 10.54499/LA/P/0069/2020), and the SEA-UP project (https://doi.org/10.54499/2023.13029.PEX). This work was also supported by the project BEAP-MAR (EAPA 0032/2022—Blue Bioeconomy in the Atlantic Area: New Products from Marine Organisms) funded by the Interreg Atlantic Area and co-funded by the European Union. Susete Pinteus acknowledges the financial support of the FCT through 2023.06631.CEECIND. Sandro Amador is a recipient of a research fellowship from “la Caixa” Foundation under the grant agreement (LCF/TR/CI23/56000027). Margarida Matias is a recipient of the Technological University of the Shannon RUN-EU European University’ postgraduate research PhD fellowship award supported by the Higher Education Authority of Ireland.
dc.identifier.citationAmador, S.; Martins, A.; Matias, M.; Pedrosa, R.; Pinteus, S. Deep Eutectic Systems: A Game Changer for Marine Bioactives Recovery. Mar. Drugs 2025, 23, 211. https://doi.org/10.3390/ md23050211
dc.identifier.doi10.3390/md23050211
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10400.8/13544
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI AG
dc.relationMarine and Environmental Sciences Centre
dc.relation.hasversionhttps://www.mdpi.com/1660-3397/23/5/211
dc.relation.ispartofMarine Drugs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBlue bioeconomy
dc.subjectDeep eutectic systems
dc.subjectMarine-derived compounds
dc.subjectNew-generation solvents
dc.subjectSustainable extraction technologies
dc.titleDeep Eutectic Systems: A Game Changer for Marine Bioactives Recoveryeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04292%2F2020/PT
oaire.citation.endPage17
oaire.citation.issue5
oaire.citation.startPage1
oaire.citation.titleMarine Drugs
oaire.citation.volume23
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameMartins
person.familyNameMoreira Fernandes Matias
person.familyNamePedrosa
person.familyNamePinteus
person.givenNameAlice
person.givenNameMargarida
person.givenNameRui
person.givenNameSusete
person.identifier349272
person.identifier159292
person.identifier.ciencia-idDA19-728A-9BC8
person.identifier.ciencia-id2B11-AC77-D7F9
person.identifier.ciencia-id3817-33DE-919E
person.identifier.ciencia-id661E-9677-74C5
person.identifier.orcid0000-0002-0542-2662
person.identifier.orcid0000-0002-8866-2564
person.identifier.orcid0000-0003-0970-0575
person.identifier.orcid0000-0002-3290-3111
person.identifier.ridB-4815-2015
person.identifier.scopus-author-id56013514200
person.identifier.scopus-author-id7005010300
person.identifier.scopus-author-id55655328300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
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