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Bacteria: Potential Make-or-Break Determinants of Celiac Disease

dc.contributor.authorRoque, Ana
dc.contributor.authorPereira, Sónia Gonçalves
dc.date.accessioned2024-02-23T11:23:07Z
dc.date.available2024-02-23T11:23:07Z
dc.date.issued2024-02-08
dc.date.updated2024-02-12T07:18:52Z
dc.descriptionFunding: This research was supported by a 2022 Beyond Celiac Established Investigator Award (BeyondCeliac.org) and by Fundação para a Ciência e Tecnologia under the grants UIDB/05704/2020 for the research unit, UI/BD/151038/2021 for Ana Roque, and CEECINST/00051/2018 (https://doi.org/10.54499/CEECINST/00051/2018/CP1566/CT0004) for Sónia Gonçalves Pereira.pt_PT
dc.description.abstractCeliac disease is an autoimmune disease triggered by dietary gluten in genetically susceptible individuals that primarily affects the small intestinal mucosa. The sole treatment is a gluten-free diet that places a social and economic burden on patients and fails, in some, to lead to symptomatic or mucosal healing. Thus, an alternative treatment has long been sought after. Clinical studies on celiac disease have shown an association between the presence of certain microbes and disease outcomes. However, the mechanisms that underlie the effects of microbes in celiac disease remain unclear. Recent studies have employed disease models that have provided insights into disease mechanisms possibly mediated by bacteria in celiac disease. Here, we have reviewed the bacteria and related mechanisms identified so far that might protect from or incite the development of celiac disease. Evidence indicates bacteria play a role in celiac disease and it is worth continuing to explore this, particularly since few studies, to the best of our knowledge, have focused on establishing a mechanistic link between bacteria and celiac disease. Uncovering host–microbe interactions and their influence on host responses to gluten may enable the discovery of pathogenic targets and development of new therapeutic or preventive approaches.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRoque, A.; Pereira, S.G. Bacteria: Potential Make-or-Break Determinants of Celiac Disease. Int. J. Mol. Sci. 2024, 25, 2090. https:// doi.org/10.3390/ijms25042090pt_PT
dc.identifier.doihttps://doi.org/10.3390/ijms25042090pt_PT
dc.identifier.eissn1422-0067
dc.identifier.slugcv-prod-3773502
dc.identifier.urihttp://hdl.handle.net/10400.8/9472
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationCenter for Innovative Care and Health Technology
dc.relationFatores biopsicossociais da doença celíaca: impactos e relações
dc.relationNot Available
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/25/4/2090pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBacteriapt_PT
dc.subjectMicrobiotapt_PT
dc.subjectHost–microbe interactionspt_PT
dc.subjectDisease mechanismspt_PT
dc.subjectCeliac diseasept_PT
dc.titleBacteria: Potential Make-or-Break Determinants of Celiac Diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCenter for Innovative Care and Health Technology
oaire.awardTitleFatores biopsicossociais da doença celíaca: impactos e relações
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05704%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//UI%2FBD%2F151038%2F2021/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00051%2F2018%2FCP1566%2FCT0001/PT
oaire.citation.issue4pt_PT
oaire.citation.startPage2090pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume25pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC INST 2018
person.familyNameRoque
person.familyNameGonçalves Pereira
person.givenNameAna
person.givenNameSónia
person.identifier461252
person.identifier.ciencia-id371E-59E7-1656
person.identifier.ciencia-idEB1F-4DB2-B0C9
person.identifier.orcid0000-0001-8226-3151
person.identifier.orcid0000-0001-8197-1850
person.identifier.ridM-7588-2017
person.identifier.scopus-author-id7202024712
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid8615-92D1-7858 | Sónia Gonçalves Pereira
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication96ab010e-dac8-4e93-8246-3acded8af87a
relation.isAuthorOfPublication259ad2cc-f9ff-4c33-ad6d-10f5b3ff341a
relation.isAuthorOfPublication.latestForDiscovery96ab010e-dac8-4e93-8246-3acded8af87a
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