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Dietary patterns drive loss of fiber-foraging species in the celiac disease patients gut microbiota compared to first-degree relatives

2024-10-08Journal article Open access
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dc.contributor.authorRoque, Ana
dc.contributor.authorZanker, Joyce
dc.contributor.authorBrígido, Sara
dc.contributor.authorTomaz, Maria Beatriz
dc.contributor.authorGonçalves, André
dc.contributor.authorBarbeiro, Sandra
dc.contributor.authorBenítez-Páez, Alfonso
dc.contributor.authorPereira, Sónia Gonçalves
dc.date.accessioned2024-10-18T16:29:46Z
dc.date.available2024-10-18T16:29:46Z
dc.date.issued2024-10-08
dc.date.updated2024-10-17T09:02:25Z
dc.descriptionThis research was supported by a 2022 Beyond Celiac Established Investigator Award (BeyondCeliac.org) and Fundação para a Ciência e Tecnologia under the grants UI/BD/151038/2021 (https://doi.org/https://doi.org/10.54499/UI/BD/151038/2021) for AR, CEECINST/00051/2018 (https://doi.org/https://doi.org/10.54499/CEECINST/00051/2018/CP1566/CT0004) for SGP, and UIDB/05704/2020 for ciTechCare, by the Institute of Health Carlos III (ISCIII) via CP19/00132 grant to AB-P, with funds from the European Social Fund (ESF/FSE).pt_PT
dc.description.abstractBackground Celiac disease is an autoimmune disorder triggered by dietary gluten in genetically predisposed indi‑viduals that primarily afects the small intestine. Studies have reported diferentially abundant bacterial taxa in the gut microbiota of celiac patients compared with non-celiac controls. However, fndings across studies have inconsisten‑cies and no microbial signature of celiac disease has been defned so far. Results Here, we showed, by comparing celiac patients with their non-celiac 1st-degree relatives, that bacterial com‑munities of related individuals have similar species occurrence and abundance compared with non-relatives, regard‑less the disease status. We also found in celiac patients a loss of bacterial species associated with fber degradation,and host metabolic and immune modulation, as ruminiclostridia, ruminococci, Prevotella, and Akkermansia muciniphila species. We demonstrated that the diferential abundance of bacterial species correlates to diferent dietary pat‑terns observed between the two groups. For instance, Ruminiclostridium siraeum, Ruminococcus bicirculans, and Bacteroides plebeious, recognized as fber-degraders, appear more abundant in non-celiac 1st-degree relatives, which havea vegetable consumption pattern higher than celiac patients. Pattern of servings per day also suggests a possible link between these species’ abundance and daily calorie intake. Conclusions Overall, we evidenced that a kinship approach could be valuable in unveiling potential celiac disease microbial traits, as well as the signifcance of dietary factors in shaping microbial profles and their infuence on dis‑ease development and progression. Our results pave the way for designing and adopting novel dietary strategies based on gluten-free fber-enriched ingredients to improve disease management and patients’ quality of life.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRoque, A., Zanker, J., Brígido, S. et al. Dietary patterns drive loss of fiber-foraging species in the celiac disease patients gut microbiota compared to first-degree relatives. Gut Pathog 16, 58 (2024). https://doi.org/10.1186/s13099-024-00643-7pt_PT
dc.identifier.doihttps://doi.org/10.1186/s13099-024-00643-7pt_PT
dc.identifier.eissn1757-4749
dc.identifier.other58
dc.identifier.slugcv-prod-4171211
dc.identifier.urihttp://hdl.handle.net/10400.8/10188
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMCpt_PT
dc.relationFatores biopsicossociais da doença celíaca: impactos e relações
dc.relationNot Available
dc.relationNot Available
dc.relation.publisherversionhttps://gutpathogens.biomedcentral.com/articles/10.1186/s13099-024-00643-7pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCeliac diseasept_PT
dc.subjectGut microbiotapt_PT
dc.subjectFiber-degraderspt_PT
dc.subjectAkkermansiapt_PT
dc.subjectRuminococci bacteriapt_PT
dc.subjectGluten-free dietpt_PT
dc.titleDietary patterns drive loss of fiber-foraging species in the celiac disease patients gut microbiota compared to first-degree relativespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleFatores biopsicossociais da doença celíaca: impactos e relações
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//UI%2FBD%2F151038%2F2021/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00051%2F2018%2FCP1566%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00051%2F2018%2FCP1566%2FCT0004/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F05704%2F2020/PT
oaire.citation.endPage13pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleGut Pathogenspt_PT
oaire.citation.volume16pt_PT
oaire.fundingStreamCEEC INST 2018
oaire.fundingStreamCEEC INST 2018
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Base
person.familyNameRoque
person.familyNameGonçalves Pereira
person.givenNameAna
person.givenNameSónia
person.identifier461252
person.identifier.ciencia-id371E-59E7-1656
person.identifier.ciencia-idEB1F-4DB2-B0C9
person.identifier.orcid0000-0001-8226-3151
person.identifier.orcid0000-0001-8197-1850
person.identifier.ridM-7588-2017
person.identifier.scopus-author-id7202024712
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid8615-92D1-7858 | Sónia Gonçalves Pereira
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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