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Depressed, hypertense and sore: Long-term effects of fluoxetine, propranolol and diclofenac exposure in a top predator fish

2020Journal article Restricted access
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dc.contributor.authorDuarte, Irina A.
dc.contributor.authorRies-Santos, Patrick
dc.contributor.authorNovais, Sara C.
dc.contributor.authorRato, Lénia D.
dc.contributor.authorLemos, Marco F.L.
dc.contributor.authorFreitas, Andreia
dc.contributor.authorPouca, Ana Sofia Vila
dc.contributor.authorBarbosa, Jorge
dc.contributor.authorCabral, Henrique N.
dc.contributor.authorFonseca, Vanessa F.
dc.date.accessioned2020-08-17T11:30:09Z
dc.date.available2020-08-17T11:30:09Z
dc.date.issued2020
dc.descriptionThis study had the support of Fundação para a Ciência e a Tecnologia (FCT) via UID/MAR/04292/2019 and project grant PTDC/MAR-EST/3048/2014. IAD was funded with an FCT PhD grant (SFRH/BD/138376/2018), PRS was funded with an FCT postdoctoral grant (SFRH/BPD/95784/2013) and VFF was funded with an FCT researcher contract (DL57/2016/CP1479/CT0024) at FCUL. The project was also partially funded by the Integrated Programme of SR&TD “SmartBioR” (reference Centro-01-0145-FEDER-000018) cofunded by Centro 2020 program, Portugal2020, European Union, through the European Regional Development Fund.pt_PT
dc.description.abstractPharmaceutical compounds are continuously released into the aquatic environment, resulting in their ubiquitous presence in many estuarine and coastal systems. As pharmaceuticals are designed to produce effects at very low concentrations and target specific evolutionary conserved pathways, there are growing concerns over their potential deleterious effects to the environment and specifically to aquatic organisms, namely in early life-stages. In this context, the long-term effects of exposure of juvenile meagre Argyrosomus regius to three different pharmaceuticals were investigated. Fish were exposed to environmental concentrations of one of three major used pharmaceuticals: the antidepressant fluoxetine (0.3 and 3 μg/L for 15 days), the anti-hypertensive propranolol and the non-steroidal anti-inflammatory agent diclofenac (0.3 and 15 μg/L for 30 days). Pharmaceuticals bioconcentration in fish muscle was examined, along with biomarkers in different tissues related with antioxidant and biotransformation responses (catalase, superoxide dismutase, ethoxyresorufin-O-deethylase and glutathione S-transferase), energetic metabolism (lactate dehydrogenase, isocitrate dehydrogenase and electron transport systemactivities), neurotransmission (acetylcholinesterase activity) and oxidative damage (DNA damage and lipid peroxidation levels). Overall, each pharmaceutical had different potential for bioconcentration in the muscle (FLX N PROP N DCF) and induced different biological responses: fluoxetine was the most toxic compound to juvenile meagre, affecting fish growth, triggering antioxidant defense responses, inhibiting detoxification mechanisms and increasing lipid peroxidation and DNA damage in the liver; propranolol exposure increased DNA damage and decreased aerobic metabolism in fish muscle; and diclofenac showed no potential to bioconcentrate, yet it affected fish metabolism by increasing cellular energy consumption in the muscle and consequently reducing fish net energy budget. The diverse response patterns evidence the need for future research focused on pharmaceuticals with different modes of action and their exposure effects on organismal physiological mechanisms and homeostatic status. Ultimately, the combination of sub-individual and individual responses is key for ecologically relevant assessments of pharmaceutical toxicity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDuarte, I. A., Reis-Santos, P., Novais, S. C., Rato, L. D., Lemos, M., Freitas, A., Pouca, A., Barbosa, J., Cabral, H. N., & Fonseca, V. F. (2020). Depressed, hypertense and sore: Long-term effects of fluoxetine, propranolol and diclofenac exposure in a top predator fish. The Science of the total environment, 712, 136564. https://doi.org/10.1016/j.scitotenv.2020.136564pt_PT
dc.identifier.doi10.1016/j.scitotenv.2020.136564pt_PT
dc.identifier.issn0048-9697
dc.identifier.urihttp://hdl.handle.net/10400.8/5087
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationMARE - Marine and Environmental Sciences Centre
dc.relationPharmaceuticals in the environment: occurrence and exposure effects in non-target fish species
dc.relationBIOCONNECT - CONECTIVIDADE EM POPULAÇÕES DE PEIXES ESTUARINOS E COSTEIROS: MARCADORES NATURAIS COMO UM INSTRUMENTO PARA GESTÃO E CONSERVAÇÃO
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectPharmaceuticalspt_PT
dc.subjectBioconcentrationpt_PT
dc.subjectGrowthpt_PT
dc.subjectEnergy metabolismpt_PT
dc.subjectOxidative stresspt_PT
dc.subjectNeurotoxicitypt_PT
dc.titleDepressed, hypertense and sore: Long-term effects of fluoxetine, propranolol and diclofenac exposure in a top predator fishpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMARE - Marine and Environmental Sciences Centre
oaire.awardTitlePharmaceuticals in the environment: occurrence and exposure effects in non-target fish species
oaire.awardTitleBIOCONNECT - CONECTIVIDADE EM POPULAÇÕES DE PEIXES ESTUARINOS E COSTEIROS: MARCADORES NATURAIS COMO UM INSTRUMENTO PARA GESTÃO E CONSERVAÇÃO
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMAR%2F04292%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMAR-EST%2F3048%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F138376%2F2018/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F95784%2F2013/PT
oaire.citation.titleScience of the Total Environmentpt_PT
oaire.citation.volume712pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStreamOE
person.familyNameNovais
person.familyNameRato
person.familyNameLemos
person.givenNameSara
person.givenNameLénia
person.givenNameMarco
person.identifier996337
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person.identifier.orcid0000-0001-9887-1864
person.identifier.ridA-9032-2012
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person.identifier.scopus-author-id23025463300
person.identifier.scopus-author-id57196186743
person.identifier.scopus-author-id7006042884
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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