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Insights into the mechanisms of Cronobacter sakazakii virulence

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dc.contributor.authorPhair, Katie
dc.contributor.authorPereira, Sónia Gonçalves
dc.contributor.authorKealey, Carmel
dc.contributor.authorFanning, Séamus
dc.contributor.authorBrady, Damien B.
dc.date.accessioned2022-07-14T10:40:23Z
dc.date.available2022-07-14T10:40:23Z
dc.date.issued2022
dc.date.updated2022-07-11T07:38:20Z
dc.description.abstractCronobacter species have adapted to survive harsh conditions, particularly in the food manufacture environment, and can cause life-threatening infections in susceptible hosts. These opportunistic pathogens employ a multitude of mechanisms to aid their virulence throughout three key stages: environmental persistence, infection strategy, and systemic persistence in the human host. Environmental persistence is aided by the formation of biofilms, development of subpopulations, and high tolerance to environmental stressors. Successful infection in the human host involves several mechanisms such as protein secretion, motility, quorum sensing, colonisation, and translocation. Survival inside the host is achieved via competitive acquisition and utilization of minerals and metabolites respectively, coupled with host immune system evasion and antimicrobial resistance (AMR) mechanisms. Across the globe, Cronobacter sakazakii is associated with often fatal systemic infections in populations including neonates, infants, the elderly and the immunocompromised. By providing insight into the mechanisms of virulence utilised by this pathogen across these three stages, this review identifies current gaps in the literature. Further research into these virulence mechanisms is required to inform novel mitigation measures to improve global food safety with regards to this food-borne pathogen.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationKatie Phair, Sónia Gonçalves Pereira, Carmel Kealey, Séamus Fanning, Damien B. Brady, Insights into the mechanisms of Cronobacter sakazakii virulence, Microbial Pathogenesis, Volume 169, 2022, 105643, ISSN 0882-4010, https://doi.org/10.1016/j.micpath.2022.105643.pt_PT
dc.identifier.doi10.1016/j.micpath.2022.105643pt_PT
dc.identifier.issn0882-4010
dc.identifier.slugcv-prod-3011014
dc.identifier.urihttp://hdl.handle.net/10400.8/7364
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationGOIPG/2021/1257pt_PT
dc.relationCEECINST/00051/2018pt_PT
dc.relationCenter for Innovative Care and Health Technology
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S088240102200256Xpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCronobacter sakazakiipt_PT
dc.subjectVirulence mechanismspt_PT
dc.subjectPathogenesispt_PT
dc.subjectEnvironmental persistencept_PT
dc.subjectSystemic infectionpt_PT
dc.titleInsights into the mechanisms of Cronobacter sakazakii virulencept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCenter for Innovative Care and Health Technology
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05704%2F2020/PT
oaire.citation.titleMicrobial Pathogenesispt_PT
oaire.citation.volume169pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameGonçalves Pereira
person.givenNameSónia
person.identifier461252
person.identifier.ciencia-idEB1F-4DB2-B0C9
person.identifier.orcid0000-0001-8197-1850
person.identifier.ridM-7588-2017
person.identifier.scopus-author-id7202024712
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid8615-92D1-7858 | Sónia Gonçalves Pereira
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication259ad2cc-f9ff-4c33-ad6d-10f5b3ff341a
relation.isAuthorOfPublication.latestForDiscovery259ad2cc-f9ff-4c33-ad6d-10f5b3ff341a
relation.isProjectOfPublicationd421b07d-3471-4026-aa43-def80b8e142b
relation.isProjectOfPublication.latestForDiscoveryd421b07d-3471-4026-aa43-def80b8e142b

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