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Magnesium oxide coatings on thermoplastic polyurethane as a key approach to prevent catheter-associated infections

2025-05Artigo científico Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.fosEngenharia e Tecnologia::Engenharia dos Materiais
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorPadrão, Tatiana
dc.contributor.authorMonteiro, Fernando J.
dc.contributor.authorSousa, Susana R.
dc.contributor.authorDias, Juliana R.
dc.date.accessioned2026-09-08T16:13:20Z
dc.date.available2026-09-08T16:13:20Z
dc.date.issued2025-05
dc.date.updated2026-09-02T15:54:19Z
dc.descriptionVolume 51, Issue 12, Part A, May 2025, Pages 15402-15415
dc.descriptionAcknowledgements This work was financially supported by the Fundação para a Ciência e a Tecnologia (FCT) through the Strategic Projects granted to CDRSP: UIDB/04044/2020 (https://doi.org/10.54499/UIDB/04044/2020), UIDP/04044/2020 (https://doi.org/10.54499/UIDP/04044/2020), to the Associate Laboratory ARISE (LA/P/0112/2020) and PTCentroDiH project (03/C16-i03/2022-768); the grant awarded to Tatiana Padrão 10.54499/2020.09198.BD (https://doi.org/10.54499/2020.09198.BD) and the funding to Juliana Dias (10.54499/CEECINST/00060/2021/CP2902/CT0005). This study was also supported by "OP-SMARTherapy, 2022.04238.PTDC", “InnovaBIOMAS, 2022.10564.PTDC”, INOV.AM – Inovação em Fabricação Aditiva, 02-C05-i01.01–2022, PC644865234-00000004 (WP14) and by European Union through PREDICTOS "PREDICTOS, 101079372". This study was also supported by i3s -Instituto de investigação e Inovação em Saúde da Universidade do Porto (POCI-01-0145-FEDER-007274), financed by FEDER – Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 and Portugal 2020. The authors would like to acknowledge to the i3S Scientific Platforms, members of the national infrastructure PPBI – Portuguese Platform of Bioimaging (PPBI-POCI-01-0145-FEDER-022122 and UIDB/04293/2020). Specially we acknowledge Ricardo Vidal from Bio interfaces and Nanotechnology platform for the assistance in FTIR, contact angle and zeta potential, as well as to Sofia Pacheco and Rui Fernandes from Histology and Electron Microscopy platform for TEM imaging. The authors also acknowledge Rui Rocha from CEMUP-Centro de Materiais da Universidade do Porto for his assistance in SEM analysis.
dc.description.abstractCentral venous catheters (CVCs) are essential healthcare tools, but their use is often complicated by bacterial colonization on the catheter surface, leading to serious infections and life-threatening bloodstream complications. Current strategies, often reliant on antibiotics or antiseptics, are increasingly ineffective due to the rise of antimicrobial resistance. This study aimed to develop a novel antibacterial coating for CVCs by incorporating magnesium oxide (MgO) nanoparticles onto a thermoplastic polyurethane (TPU) film surface containing barium sulfate (BaSO4). The antibacterial efficacy of these coatings was evaluated against Staphylococcus epidermidis, a major pathogen in catheter-associated infections. The results showed that MgO coatings significantly inhibited bacterial growth in a concentration-dependent manner, with 0.50 % and 1.0 % MgO concentrations achieving complete eradication of both planktonic and adherent bacteria. Importantly, the coatings exhibited excellent cytocompatibility with fibroblasts and showed no significant impact on hemolysis or blood clotting. The 0.50 % MgO coating was identified as the optimal formulation, offering the best balance of potent antibacterial activity, cytocompatibility and hemocompatibility. This approach preserves the valuable physical and chemical properties of the TPU material while providing effective antibacterial protection. The straightforward and cost-effective coating process holds significant promise for industrial scale production, paving the way for a new generation of safer and more effective CVCs.eng
dc.description.sponsorshipThis work was financially supported by: - the Fundação para a Ciência e a Tecnologia (FCT) through the Strategic Projects granted to CDRSP: UIDB/04044/2020 (https://doi.org/10.54499/UIDB/04044/2020), UIDP/04044/2020 (https://doi.org/10.54499/UIDP/04044/2020),; - to the Associate Laboratory ARISE (LA/P/0112/2020) and PTCentroDiH project (03/C16-i03/2022-768); - the grant awarded to Tatiana Padrão 10.54499/2020.09198.BD (https://doi.org/10.54499/2020.09198.BD) - and the funding to Juliana Dias (10.54499/CEECINST/00060/2021/CP2902/CT0005).
dc.description.sponsorshipThis study was also supported by: - "OP-SMARTherapy, 2022.04238.PTDC", “InnovaBIOMAS, 2022.10564.PTDC”, INOV.AM – Inovação em Fabricação Aditiva, 02-C05-i01.01–2022, PC644865234-00000004 (WP14) and by European Union through PREDICTOS "PREDICTOS, 101079372". This study was also supported by i3s -Instituto de investigação e Inovação em Saúde da Universidade do Porto (POCI-01-0145-FEDER-007274), financed by FEDER – Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 and Portugal 2020.
dc.description.sponsorship- The authors would like to acknowledge to the i3S Scientific Platforms, members of the national infrastructure PPBI – Portuguese Platform of Bioimaging (PPBI-POCI-01-0145-FEDER-022122 and UIDB/04293/2020). Specially we acknowledge Ricardo Vidal from Bio interfaces and Nanotechnology platform for the assistance in FTIR, contact angle and zeta potential, as well as to Sofia Pacheco and Rui Fernandes from Histology and Electron Microscopy platform for TEM imaging. The authors also acknowledge Rui Rocha from CEMUP-Centro de Materiais da Universidade do Porto for his assistance in SEM analysis.
dc.description.versionN/A
dc.identifier.citationPadrão, T., Monteiro, F. J., Sousa, S. R., & Dias, J. R. (2025). Magnesium oxide coatings on thermoplastic polyurethane as a key approach to prevent catheter-associated infections. Ceramics International, 51, 15402–15415. https://doi.org/10.1016/j.ceramint.2025.01.376
dc.identifier.doi10.1016/j.ceramint.2025.01.376en_US
dc.identifier.eid2-s2.0-105003102645en_US
dc.identifier.issn0272-8842en_US
dc.identifier.slugcv-prod-4335353
dc.identifier.urihttp://hdl.handle.net/10400.8/16815
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationAdvanced Production and Intelligent Systems
dc.relation3D-printed medical devices based on antimicrobial polymeric composites to prevent hospital-acquired infections
dc.relationStimuli-responsive bone-like magnetic scaffolds with osteoimmunomodulatory effect for prevention of osteoporosis related fractures
dc.relationStrengthening excellence for advanced osteosarcoma’s predictive models
dc.relationInstitute for Research and Innovation in Health
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0272884225004134
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAntibacterial
dc.subjectCatheter
dc.subjectInfection
dc.subjectMagnesium oxide
dc.subjectNanoparticles
dc.subjectPolyurethane
dc.titleMagnesium oxide coatings on thermoplastic polyurethane as a key approach to prevent catheter-associated infectionseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDB/04044/2020
oaire.awardNumberUIDP/04044/2020
oaire.awardNumberLA/P/0112/2020
oaire.awardNumber2020.09198.BD
oaire.awardNumber2022.04238.PTDC
oaire.awardNumber101079372
oaire.awardNumberUIDB/04293/2020
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleAdvanced Production and Intelligent Systems
oaire.awardTitle3D-printed medical devices based on antimicrobial polymeric composites to prevent hospital-acquired infections
oaire.awardTitleStimuli-responsive bone-like magnetic scaffolds with osteoimmunomodulatory effect for prevention of osteoporosis related fractures
oaire.awardTitleStrengthening excellence for advanced osteosarcoma’s predictive models
oaire.awardTitleInstitute for Research and Innovation in Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04044%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04044%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0112%2F2020/PT
oaire.awardURIhttp://hdl.handle.net/10400.8/16811
oaire.awardURIhttp://hdl.handle.net/10400.8/16812
oaire.awardURIhttp://hdl.handle.net/10400.8/16813
oaire.awardURIhttp://hdl.handle.net/10400.8/16814
oaire.citation.endPage15415
oaire.citation.issue12
oaire.citation.startPage15402
oaire.citation.titleCeramics Internationalen_US
oaire.citation.volume51
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso de Projetos de I&D em Todos os Domínios Científicos - 2022 - PEX
oaire.fundingStreamHORIZON Action Grant Budget-Based
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Base
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNamePadrão
person.familyNameDias
person.givenNameTatiana
person.givenNameJuliana
person.identifier633669
person.identifier.ciencia-id0612-D971-F00D
person.identifier.orcid0000-0003-1198-8977
person.identifier.orcid0000-0002-7079-1069
person.identifier.ridA-6086-2014
person.identifier.scopus-author-id55749822200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid0612-D971-F00D | Juliana Rosa Dias
rcaap.rightsopenAccessen_US
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