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Orientador(es)
Resumo(s)
Central venous catheters (CVCs) are essential healthcare tools, but their use is often complicated by bacterial colonization on the catheter surface, leading to serious infections and life-threatening bloodstream complications. Current strategies, often reliant on antibiotics or antiseptics, are increasingly ineffective due to the rise of antimicrobial resistance. This study aimed to develop a novel antibacterial coating for CVCs by incorporating magnesium oxide (MgO) nanoparticles onto a thermoplastic polyurethane (TPU) film surface containing barium sulfate (BaSO4). The antibacterial efficacy of these coatings was evaluated against Staphylococcus epidermidis, a major pathogen in catheter-associated infections. The results showed that MgO coatings significantly inhibited bacterial growth in a concentration-dependent manner, with 0.50 % and 1.0 % MgO concentrations achieving complete eradication of both planktonic and adherent bacteria. Importantly, the coatings exhibited excellent cytocompatibility with fibroblasts and showed no significant impact on hemolysis or blood clotting. The 0.50 % MgO coating was identified as the optimal formulation, offering the best balance of potent antibacterial activity, cytocompatibility and hemocompatibility. This approach preserves the valuable physical and chemical properties of the TPU material while providing effective antibacterial protection. The straightforward and cost-effective coating process holds significant promise for industrial scale production, paving the way for a new generation of safer and more effective CVCs.
Descrição
Volume 51, Issue 12, Part A, May 2025, Pages 15402-15415
Acknowledgements This work was financially supported by the Fundação para a Ciência e a Tecnologia (FCT) through the Strategic Projects granted to CDRSP: UIDB/04044/2020 (https://doi.org/10.54499/UIDB/04044/2020), UIDP/04044/2020 (https://doi.org/10.54499/UIDP/04044/2020), to the Associate Laboratory ARISE (LA/P/0112/2020) and PTCentroDiH project (03/C16-i03/2022-768); the grant awarded to Tatiana Padrão 10.54499/2020.09198.BD (https://doi.org/10.54499/2020.09198.BD) and the funding to Juliana Dias (10.54499/CEECINST/00060/2021/CP2902/CT0005). This study was also supported by "OP-SMARTherapy, 2022.04238.PTDC", “InnovaBIOMAS, 2022.10564.PTDC”, INOV.AM – Inovação em Fabricação Aditiva, 02-C05-i01.01–2022, PC644865234-00000004 (WP14) and by European Union through PREDICTOS "PREDICTOS, 101079372". This study was also supported by i3s -Instituto de investigação e Inovação em Saúde da Universidade do Porto (POCI-01-0145-FEDER-007274), financed by FEDER – Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 and Portugal 2020. The authors would like to acknowledge to the i3S Scientific Platforms, members of the national infrastructure PPBI – Portuguese Platform of Bioimaging (PPBI-POCI-01-0145-FEDER-022122 and UIDB/04293/2020). Specially we acknowledge Ricardo Vidal from Bio interfaces and Nanotechnology platform for the assistance in FTIR, contact angle and zeta potential, as well as to Sofia Pacheco and Rui Fernandes from Histology and Electron Microscopy platform for TEM imaging. The authors also acknowledge Rui Rocha from CEMUP-Centro de Materiais da Universidade do Porto for his assistance in SEM analysis.
Acknowledgements This work was financially supported by the Fundação para a Ciência e a Tecnologia (FCT) through the Strategic Projects granted to CDRSP: UIDB/04044/2020 (https://doi.org/10.54499/UIDB/04044/2020), UIDP/04044/2020 (https://doi.org/10.54499/UIDP/04044/2020), to the Associate Laboratory ARISE (LA/P/0112/2020) and PTCentroDiH project (03/C16-i03/2022-768); the grant awarded to Tatiana Padrão 10.54499/2020.09198.BD (https://doi.org/10.54499/2020.09198.BD) and the funding to Juliana Dias (10.54499/CEECINST/00060/2021/CP2902/CT0005). This study was also supported by "OP-SMARTherapy, 2022.04238.PTDC", “InnovaBIOMAS, 2022.10564.PTDC”, INOV.AM – Inovação em Fabricação Aditiva, 02-C05-i01.01–2022, PC644865234-00000004 (WP14) and by European Union through PREDICTOS "PREDICTOS, 101079372". This study was also supported by i3s -Instituto de investigação e Inovação em Saúde da Universidade do Porto (POCI-01-0145-FEDER-007274), financed by FEDER – Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 and Portugal 2020. The authors would like to acknowledge to the i3S Scientific Platforms, members of the national infrastructure PPBI – Portuguese Platform of Bioimaging (PPBI-POCI-01-0145-FEDER-022122 and UIDB/04293/2020). Specially we acknowledge Ricardo Vidal from Bio interfaces and Nanotechnology platform for the assistance in FTIR, contact angle and zeta potential, as well as to Sofia Pacheco and Rui Fernandes from Histology and Electron Microscopy platform for TEM imaging. The authors also acknowledge Rui Rocha from CEMUP-Centro de Materiais da Universidade do Porto for his assistance in SEM analysis.
Palavras-chave
Antibacterial Catheter Infection Magnesium oxide Nanoparticles Polyurethane
Contexto Educativo
Citação
Padrão, T., Monteiro, F. J., Sousa, S. R., & Dias, J. R. (2025). Magnesium oxide coatings on thermoplastic polyurethane as a key approach to prevent catheter-associated infections. Ceramics International, 51, 15402–15415. https://doi.org/10.1016/j.ceramint.2025.01.376
Editora
Elsevier